Transamidation of primary amides with amines using hydroxylamine hydrochloride as an inorganic catalyst

Clare L Allen, Benjamin N Atkinson, Jonathan M J Williams

Research output: Contribution to journalArticlepeer-review

160 Citations (Scopus)

Abstract

Metal-free catalysis: A method for the transamidation of primary amides with primary or secondary amines provides access to secondary and tertiary amides, by utilizing catalytic quantities of hydroxylamine hydrochloride to activate the chemically robust primary amide group (see scheme). A mechanism of primary amide activation through a hydrogen-bonding complex is proposed.
Original languageEnglish
Pages (from-to)1383-1386
Number of pages4
JournalAngewandte Chemie-International Edition
Volume51
Issue number6
DOIs
Publication statusPublished - 6 Feb 2012

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