Toxic shock syndrome toxin-1 challenges the neuroprotective functions of the choroidal epithelium and induces neurotoxicity

M Batisson, N Strazielle, M Hejmadi, D Thomas, J F Ghersi-Egea, J Etienne, F Vandenesch, G Lina

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

To probe encephalopathy pathogenesis during toxic shock syndrome (TSS), we investigated the fate of blood-borne TSS toxin-1 (TSST-1) as it moves through the choroid plexus epithelium that forms the main blood cerebrospinal fluid (CSF) barrier and the effect that TSST-1 has on choroidal barrier properties and on cultured neuronal cell viability. TSST-1 showed a slow, diffusional movement across a cellular model of the blood-CSF barrier but did not compromise the integrity of the barrier. Relevant to the acute symptoms of TSS, a combination of human leukocytes and the toxin induced a decrease in CSF clearance of the pyrogenic prostaglandin E-2 (PGE(2)). The direct effects that TSST-1 had on primary cortical neuron cultures and a neuronal cell line involved elevated caspase 3/7 levels, which correlated with an increase in neuronal cell death. The results of the present study suggest that TSST-1 can affect the brain, by inducing both an intracerebral increase in PGE(2) concentration and caspase-dependent neuronal death, which are possibly relevant to long-term intoxication.
Original languageEnglish
Pages (from-to)341-349
Number of pages9
JournalJournal of Infectious Diseases
Volume194
Issue number3
Publication statusPublished - 2006

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