Towards clinical-dose grating interferometry breast CT with fused intensity-based iterative reconstruction

Stefano Van Gogh, Michał Rawlik, Alexandre Pereira, Simon Spindler, Subhadip Mukherjee, Marie Christine Zdora, Martin Stauber, Rima Alaifari, Zsuzsanna Varga, Marco Stampanoni

Research output: Contribution to journalArticlepeer-review

2 Citations (SciVal)


X-ray grating interferometry CT (GI-CT) is an emerging imaging modality which provides three complementary contrasts that could increase the diagnostic content of clinical breast CT: absorption, phase, and dark-field. Yet, reconstructing the three image channels under clinically compatible conditions is challenging because of severe ill-conditioning of the tomographic reconstruction problem. In this work we propose to solve this problem with a novel reconstruction algorithm that assumes a fixed relation between the absorption and the phase-contrast channel to reconstruct a single image by automatically fusing the absorption and phase channels. The results on both simulations and real data show that, enabled by the proposed algorithm, GI-CT outperforms conventional CT at a clinical dose.

Original languageEnglish
Pages (from-to)9052-9071
Number of pages20
JournalOptics Express
Issue number5
Publication statusPublished - 24 Feb 2023

Bibliographical note

Funding Information:
Funding. Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CRSII5 183568, SNF Sinergia Grant); ETH-Research Commission (ETH-12 20-2); ETH Doc.Mobility (Fellowship); Promedica Stiftung Chur; Swisslos Lottery Fund of Kanton Aargau.

Data availability
Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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