Towards clinical-dose grating interferometry breast CT with fused intensity-based iterative reconstruction

Stefano Van Gogh; Michał Rawlik; Alexandre Pereira; Simon Spindler; Subhadip Mukherjee; Marie Christine Zdora; Martin Stauber; Rima Alaifari; Zsuzsanna Varga; Marco Stampanoni

doi:10.1364/OE.484123

Towards clinical-dose grating interferometry breast CT with fused intensity-based iterative reconstruction

Stefano Van Gogh, Michał Rawlik, Alexandre Pereira, Simon Spindler, Subhadip Mukherjee, Marie Christine Zdora, Martin Stauber, Rima Alaifari, Zsuzsanna Varga, Marco Stampanoni

Department of Computer Science

Research output: Contribution to journal › Article › peer-review

3 Citations (SciVal)

Abstract

X-ray grating interferometry CT (GI-CT) is an emerging imaging modality which provides three complementary contrasts that could increase the diagnostic content of clinical breast CT: absorption, phase, and dark-field. Yet, reconstructing the three image channels under clinically compatible conditions is challenging because of severe ill-conditioning of the tomographic reconstruction problem. In this work we propose to solve this problem with a novel reconstruction algorithm that assumes a fixed relation between the absorption and the phase-contrast channel to reconstruct a single image by automatically fusing the absorption and phase channels. The results on both simulations and real data show that, enabled by the proposed algorithm, GI-CT outperforms conventional CT at a clinical dose.

Original language	English
Pages (from-to)	9052-9071
Number of pages	20
Journal	Optics Express
Volume	31
Issue number	5
DOIs	https://doi.org/10.1364/OE.484123
Publication status	Published - 24 Feb 2023

Bibliographical note

Funding Information:
Funding. Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CRSII5 183568, SNF Sinergia Grant); ETH-Research Commission (ETH-12 20-2); ETH Doc.Mobility (Fellowship); Promedica Stiftung Chur; Swisslos Lottery Fund of Kanton Aargau.

Data availability
Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OE.484123Licence: CC BY-NC

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title = "Towards clinical-dose grating interferometry breast CT with fused intensity-based iterative reconstruction",

abstract = "X-ray grating interferometry CT (GI-CT) is an emerging imaging modality which provides three complementary contrasts that could increase the diagnostic content of clinical breast CT: absorption, phase, and dark-field. Yet, reconstructing the three image channels under clinically compatible conditions is challenging because of severe ill-conditioning of the tomographic reconstruction problem. In this work we propose to solve this problem with a novel reconstruction algorithm that assumes a fixed relation between the absorption and the phase-contrast channel to reconstruct a single image by automatically fusing the absorption and phase channels. The results on both simulations and real data show that, enabled by the proposed algorithm, GI-CT outperforms conventional CT at a clinical dose.",

author = "{Van Gogh}, Stefano and Micha{\l} Rawlik and Alexandre Pereira and Simon Spindler and Subhadip Mukherjee and Zdora, {Marie Christine} and Martin Stauber and Rima Alaifari and Zsuzsanna Varga and Marco Stampanoni",

note = "Funding Information: Funding. Schweizerischer Nationalfonds zur F{\"o}rderung der Wissenschaftlichen Forschung (CRSII5 183568, SNF Sinergia Grant); ETH-Research Commission (ETH-12 20-2); ETH Doc.Mobility (Fellowship); Promedica Stiftung Chur; Swisslos Lottery Fund of Kanton Aargau. Data availability Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.",

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doi = "10.1364/OE.484123",

language = "English",

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AU - Van Gogh, Stefano

AU - Rawlik, Michał

AU - Pereira, Alexandre

AU - Spindler, Simon

AU - Mukherjee, Subhadip

AU - Zdora, Marie Christine

AU - Stauber, Martin

AU - Alaifari, Rima

AU - Varga, Zsuzsanna

AU - Stampanoni, Marco

N1 - Funding Information: Funding. Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CRSII5 183568, SNF Sinergia Grant); ETH-Research Commission (ETH-12 20-2); ETH Doc.Mobility (Fellowship); Promedica Stiftung Chur; Swisslos Lottery Fund of Kanton Aargau. Data availability Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

PY - 2023/2/24

Y1 - 2023/2/24

N2 - X-ray grating interferometry CT (GI-CT) is an emerging imaging modality which provides three complementary contrasts that could increase the diagnostic content of clinical breast CT: absorption, phase, and dark-field. Yet, reconstructing the three image channels under clinically compatible conditions is challenging because of severe ill-conditioning of the tomographic reconstruction problem. In this work we propose to solve this problem with a novel reconstruction algorithm that assumes a fixed relation between the absorption and the phase-contrast channel to reconstruct a single image by automatically fusing the absorption and phase channels. The results on both simulations and real data show that, enabled by the proposed algorithm, GI-CT outperforms conventional CT at a clinical dose.

AB - X-ray grating interferometry CT (GI-CT) is an emerging imaging modality which provides three complementary contrasts that could increase the diagnostic content of clinical breast CT: absorption, phase, and dark-field. Yet, reconstructing the three image channels under clinically compatible conditions is challenging because of severe ill-conditioning of the tomographic reconstruction problem. In this work we propose to solve this problem with a novel reconstruction algorithm that assumes a fixed relation between the absorption and the phase-contrast channel to reconstruct a single image by automatically fusing the absorption and phase channels. The results on both simulations and real data show that, enabled by the proposed algorithm, GI-CT outperforms conventional CT at a clinical dose.

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Towards clinical-dose grating interferometry breast CT with fused intensity-based iterative reconstruction

Abstract

Bibliographical note

ASJC Scopus subject areas

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