Towards clinical-dose grating interferometry breast CT with fused intensity-based iterative reconstruction

Stefano Van Gogh, Michał Rawlik, Alexandre Pereira, Simon Spindler, Subhadip Mukherjee, Marie Christine Zdora, Martin Stauber, Rima Alaifari, Zsuzsanna Varga, Marco Stampanoni

Research output: Contribution to journalArticlepeer-review

Abstract

X-ray grating interferometry CT (GI-CT) is an emerging imaging modality which provides three complementary contrasts that could increase the diagnostic content of clinical breast CT: absorption, phase, and dark-field. Yet, reconstructing the three image channels under clinically compatible conditions is challenging because of severe ill-conditioning of the tomographic reconstruction problem. In this work we propose to solve this problem with a novel reconstruction algorithm that assumes a fixed relation between the absorption and the phase-contrast channel to reconstruct a single image by automatically fusing the absorption and phase channels. The results on both simulations and real data show that, enabled by the proposed algorithm, GI-CT outperforms conventional CT at a clinical dose.

Original languageEnglish
Pages (from-to)9052-9071
Number of pages20
JournalOptics Express
Volume31
Issue number5
DOIs
Publication statusPublished - 24 Feb 2023

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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