Abstract
The advent of next-generation sequencing technology has provided unprecedented detail as to the micro-evolutionary processes impacting on bacterial genomes. These data are also leading to a powerful synthesis between evolutionary genetics, population biology, ecology and epidemiology: such a holistic approach is necessary to understand the emergence and spread of bacterial pathogens. Here the recent advances made in understanding genome dynamics within this broader epidemiological context are reviewed, and the challenges and opportunities bestowed by next-generation sequencing in the future are discussed.
| Original language | English |
|---|---|
| Title of host publication | Molecular Medical Microbiology |
| Editors | Yi-Wei Tang, Max Sussman, Dongyou Liu, Ian Poxton, Joseph Schwartzman |
| Publisher | Elsevier |
| Pages | 337-345 |
| Number of pages | 9 |
| Volume | 1 |
| Edition | Second |
| ISBN (Electronic) | 9780123971692 |
| ISBN (Print) | 9780126775303 |
| DOIs | |
| Publication status | Published - 26 Nov 2014 |
Fingerprint
Keywords
- Ecology of pathogens
- Evolutionary genetics
- Genome dynamics
- Population genetics
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Towards a Synthesis of Population Genomics and Epidemiology : Next-Generation Sequencing of Bacterial Pathogens. / Castillo-Ramirez, Santiago; Feil, Edward J.
Molecular Medical Microbiology. ed. / Yi-Wei Tang; Max Sussman; Dongyou Liu; Ian Poxton; Joseph Schwartzman. Vol. 1 Second. ed. Elsevier, 2014. p. 337-345 Chapter 18.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Towards a Synthesis of Population Genomics and Epidemiology
T2 - Next-Generation Sequencing of Bacterial Pathogens
AU - Castillo-Ramirez, Santiago
AU - Feil, Edward J.
PY - 2014/11/26
Y1 - 2014/11/26
N2 - The advent of next-generation sequencing technology has provided unprecedented detail as to the micro-evolutionary processes impacting on bacterial genomes. These data are also leading to a powerful synthesis between evolutionary genetics, population biology, ecology and epidemiology: such a holistic approach is necessary to understand the emergence and spread of bacterial pathogens. Here the recent advances made in understanding genome dynamics within this broader epidemiological context are reviewed, and the challenges and opportunities bestowed by next-generation sequencing in the future are discussed.
AB - The advent of next-generation sequencing technology has provided unprecedented detail as to the micro-evolutionary processes impacting on bacterial genomes. These data are also leading to a powerful synthesis between evolutionary genetics, population biology, ecology and epidemiology: such a holistic approach is necessary to understand the emergence and spread of bacterial pathogens. Here the recent advances made in understanding genome dynamics within this broader epidemiological context are reviewed, and the challenges and opportunities bestowed by next-generation sequencing in the future are discussed.
KW - Ecology of pathogens
KW - Evolutionary genetics
KW - Genome dynamics
KW - Population genetics
UR - http://www.scopus.com/inward/record.url?scp=84961176055&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-397169-2.00018-4
DO - 10.1016/B978-0-12-397169-2.00018-4
M3 - Chapter
SN - 9780126775303
VL - 1
SP - 337
EP - 345
BT - Molecular Medical Microbiology
A2 - Tang, Yi-Wei
A2 - Sussman, Max
A2 - Liu, Dongyou
A2 - Poxton, Ian
A2 - Schwartzman, Joseph
PB - Elsevier
ER -