Towards a Synthesis of Population Genomics and Epidemiology:  Next-Generation Sequencing of Bacterial Pathogens

Santiago Castillo-Ramirez; Edward J. Feil

doi:10.1016/B978-0-12-397169-2.00018-4

Towards a Synthesis of Population Genomics and Epidemiology: Next-Generation Sequencing of Bacterial Pathogens

Santiago Castillo-Ramirez, Edward J. Feil

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The advent of next-generation sequencing technology has provided unprecedented detail as to the micro-evolutionary processes impacting on bacterial genomes. These data are also leading to a powerful synthesis between evolutionary genetics, population biology, ecology and epidemiology: such a holistic approach is necessary to understand the emergence and spread of bacterial pathogens. Here the recent advances made in understanding genome dynamics within this broader epidemiological context are reviewed, and the challenges and opportunities bestowed by next-generation sequencing in the future are discussed.

Original language	English
Title of host publication	Molecular Medical Microbiology
Editors	Yi-Wei Tang, Max Sussman, Dongyou Liu, Ian Poxton, Joseph Schwartzman
Publisher	Elsevier
Pages	337-345
Number of pages	9
Volume	1
Edition	Second
ISBN (Electronic)	9780123971692
ISBN (Print)	9780126775303
DOIs	https://doi.org/10.1016/B978-0-12-397169-2.00018-4
Publication status	Published - 26 Nov 2014

Keywords

Ecology of pathogens
Evolutionary genetics
Genome dynamics
Population genetics

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/B978-0-12-397169-2.00018-4

Cite this

Towards a Synthesis of Population Genomics and Epidemiology : Next-Generation Sequencing of Bacterial Pathogens. / Castillo-Ramirez, Santiago; Feil, Edward J.

Molecular Medical Microbiology. ed. / Yi-Wei Tang; Max Sussman; Dongyou Liu; Ian Poxton; Joseph Schwartzman. Vol. 1 Second. ed. Elsevier, 2014. p. 337-345 Chapter 18.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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