Towards a Synthesis of Population Genomics and Epidemiology: Next-Generation Sequencing of Bacterial Pathogens

Santiago Castillo-Ramirez, Edward J. Feil

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The advent of next-generation sequencing technology has provided unprecedented detail as to the micro-evolutionary processes impacting on bacterial genomes. These data are also leading to a powerful synthesis between evolutionary genetics, population biology, ecology and epidemiology: such a holistic approach is necessary to understand the emergence and spread of bacterial pathogens. Here the recent advances made in understanding genome dynamics within this broader epidemiological context are reviewed, and the challenges and opportunities bestowed by next-generation sequencing in the future are discussed.

Original languageEnglish
Title of host publicationMolecular Medical Microbiology
EditorsYi-Wei Tang, Max Sussman, Dongyou Liu, Ian Poxton, Joseph Schwartzman
PublisherElsevier
Pages337-345
Number of pages9
Volume1
EditionSecond
ISBN (Electronic)9780123971692
ISBN (Print)9780126775303
DOIs
Publication statusPublished - 26 Nov 2014

Keywords

  • Ecology of pathogens
  • Evolutionary genetics
  • Genome dynamics
  • Population genetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Castillo-Ramirez, S., & Feil, E. J. (2014). Towards a Synthesis of Population Genomics and Epidemiology: Next-Generation Sequencing of Bacterial Pathogens. In Y-W. Tang, M. Sussman, D. Liu, I. Poxton, & J. Schwartzman (Eds.), Molecular Medical Microbiology (Second ed., Vol. 1, pp. 337-345). [Chapter 18] Elsevier. https://doi.org/10.1016/B978-0-12-397169-2.00018-4