Abstract
The advent of next-generation sequencing technology has provided unprecedented detail as to the micro-evolutionary processes impacting on bacterial genomes. These data are also leading to a powerful synthesis between evolutionary genetics, population biology, ecology and epidemiology: such a holistic approach is necessary to understand the emergence and spread of bacterial pathogens. Here the recent advances made in understanding genome dynamics within this broader epidemiological context are reviewed, and the challenges and opportunities bestowed by next-generation sequencing in the future are discussed.
| Original language | English |
|---|---|
| Title of host publication | Molecular Medical Microbiology |
| Editors | Yi-Wei Tang, Max Sussman, Dongyou Liu, Ian Poxton, Joseph Schwartzman |
| Publisher | Elsevier |
| Pages | 337-345 |
| Number of pages | 9 |
| Volume | 1 |
| Edition | Second |
| ISBN (Electronic) | 9780123971692 |
| ISBN (Print) | 9780126775303 |
| DOIs | |
| Publication status | Published - 26 Nov 2014 |
Keywords
- Ecology of pathogens
- Evolutionary genetics
- Genome dynamics
- Population genetics
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Castillo-Ramirez, S., & Feil, E. J. (2014). Towards a Synthesis of Population Genomics and Epidemiology: Next-Generation Sequencing of Bacterial Pathogens. In Y-W. Tang, M. Sussman, D. Liu, I. Poxton, & J. Schwartzman (Eds.), Molecular Medical Microbiology (Second ed., Vol. 1, pp. 337-345). [Chapter 18] Elsevier. https://doi.org/10.1016/B978-0-12-397169-2.00018-4