Toward preparative resolution of chiral alcohols by an organic chemical method

Nino Malic, Cornelius Moorhof, Valerie Sage, Dilek Saylik, Ching-Mei Teoh, Janet L. Scott, Christopher R Strauss

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Abstract

Asymmetric alcohols were resolved as 1-α-O-alkyl-2,3-unsaturated hexosides. After separation of diastereoisomers, the auxiliary and the enantiomeric alcohol were recovered by transglycosidation. Potential applications include resolution of labile secondary and tertiary alcohols, difficult by existing techniques, and enhancement of ees of chiral alcohols produced enzymatically or by synthetic catalytic methods.
LanguageEnglish
Pages398-402
Number of pages5
JournalNew Journal of Chemistry
Volume34
Issue number3
DOIs
StatusPublished - 2010

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Organic Chemicals
Organic chemicals
Alcohols

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Malic, N., Moorhof, C., Sage, V., Saylik, D., Teoh, C-M., Scott, J. L., & Strauss, C. R. (2010). Toward preparative resolution of chiral alcohols by an organic chemical method. DOI: 10.1039/b9nj00768g

Toward preparative resolution of chiral alcohols by an organic chemical method. / Malic, Nino; Moorhof, Cornelius; Sage, Valerie; Saylik, Dilek; Teoh, Ching-Mei; Scott, Janet L.; Strauss, Christopher R.

In: New Journal of Chemistry, Vol. 34, No. 3, 2010, p. 398-402.

Research output: Contribution to journalArticle

Malic, N, Moorhof, C, Sage, V, Saylik, D, Teoh, C-M, Scott, JL & Strauss, CR 2010, 'Toward preparative resolution of chiral alcohols by an organic chemical method' New Journal of Chemistry, vol. 34, no. 3, pp. 398-402. DOI: 10.1039/b9nj00768g
Malic N, Moorhof C, Sage V, Saylik D, Teoh C-M, Scott JL et al. Toward preparative resolution of chiral alcohols by an organic chemical method. New Journal of Chemistry. 2010;34(3):398-402. Available from, DOI: 10.1039/b9nj00768g
Malic, Nino ; Moorhof, Cornelius ; Sage, Valerie ; Saylik, Dilek ; Teoh, Ching-Mei ; Scott, Janet L. ; Strauss, Christopher R. / Toward preparative resolution of chiral alcohols by an organic chemical method. In: New Journal of Chemistry. 2010 ; Vol. 34, No. 3. pp. 398-402
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