TY - JOUR
T1 - Toward preparative resolution of chiral alcohols by an organic chemical method
AU - Malic, Nino
AU - Moorhof, Cornelius
AU - Sage, Valerie
AU - Saylik, Dilek
AU - Teoh, Ching-Mei
AU - Scott, Janet L.
AU - Strauss, Christopher R
PY - 2010
Y1 - 2010
N2 - Asymmetric alcohols were resolved as 1-α-O-alkyl-2,3-unsaturated hexosides. After separation of diastereoisomers, the auxiliary and the enantiomeric alcohol were recovered by transglycosidation. Potential applications include resolution of labile secondary and tertiary alcohols, difficult by existing techniques, and enhancement of ees of chiral alcohols produced enzymatically or by synthetic catalytic methods.
AB - Asymmetric alcohols were resolved as 1-α-O-alkyl-2,3-unsaturated hexosides. After separation of diastereoisomers, the auxiliary and the enantiomeric alcohol were recovered by transglycosidation. Potential applications include resolution of labile secondary and tertiary alcohols, difficult by existing techniques, and enhancement of ees of chiral alcohols produced enzymatically or by synthetic catalytic methods.
UR - http://www.scopus.com/inward/record.url?scp=77949421516&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1039/b9nj00768g
U2 - 10.1039/b9nj00768g
DO - 10.1039/b9nj00768g
M3 - Article
SN - 1144-0546
VL - 34
SP - 398
EP - 402
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 3
ER -