This chapter outlines a design-science perspective of entrepreneurship. It zooms in on the junction between present and future to distinguish entrepreneurship as a natural and as an artificial phenomenon. While the current study of entrepreneurship speaks to the former, it has been silent on the latter. The chapter discusses design as a distinct mode of research, opportunity as a design artifact, and the generative power of recursive action to make the case for problematizing entrepreneurial action as a focus of research. It then defines its research questions, discusses the logic and process for addressing them, and outlines the nature of research outputs.