Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells

Elise C Pegg, Faisal Matboli, Tim Marriott, Imran Khan, Colin A Scotchford

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A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like cells was performed on a series of BoneMaster-coated surfaces. The chemistry was separated from the topography using a thin gold coating; Thermanox coverslips were used as a control. BoneMaster surfaces showed significantly greater alkaline phosphatase activity and osteocalcin production compared with controls; however, no difference was found between the gold-coated and uncoated BoneMaster samples, indicating topography is the main contributing factor.

Original languageEnglish
Pages (from-to)946-53
Number of pages8
JournalJournal of Biomaterials Applications
Issue number6
Publication statusPublished - Feb 2014



  • Alkaline Phosphatase
  • Biomaterials
  • Coated Materials
  • Hydroxyapatite
  • Electrodeposition
  • Surface Properties
  • Osteoblasts
  • Photoelectron Spectroscopy

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