Thiol-Functionalising Reagents and Their Uses

Andrew Watts (Inventor), Terrence Kantner (Inventor), Amanda Mackenzie (Inventor)

Research output: Patent

Abstract

Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.
Original languageEnglish
Patent numberEP2373675 (A2)
IPCC07K1/13
Publication statusPublished - 12 Oct 2011

Fingerprint

Sulfhydryl Compounds
Glycols
Polysaccharides
Peptides
Molecules
Cysteine
Nitrogen

Cite this

Watts, A., Kantner, T., & Mackenzie, A. (2011). IPC No. C07K1/13. Thiol-Functionalising Reagents and Their Uses. (Patent No. EP2373675 (A2)).

Thiol-Functionalising Reagents and Their Uses. / Watts, Andrew (Inventor); Kantner, Terrence (Inventor); Mackenzie, Amanda (Inventor).

IPC No.: C07K1/13. Patent No.: EP2373675 (A2).

Research output: Patent

Watts, A, Kantner, T & Mackenzie, A 2011, Thiol-Functionalising Reagents and Their Uses, Patent No. EP2373675 (A2), IPC No. C07K1/13.
Watts A, Kantner T, Mackenzie A, inventors. Thiol-Functionalising Reagents and Their Uses. C07K1/13. 2011 Oct 12.
Watts, Andrew (Inventor) ; Kantner, Terrence (Inventor) ; Mackenzie, Amanda (Inventor). / Thiol-Functionalising Reagents and Their Uses. IPC No.: C07K1/13. Patent No.: EP2373675 (A2).
@misc{7d06a97a308b4cfbbb9753beab103f56,
title = "Thiol-Functionalising Reagents and Their Uses",
abstract = "Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.",
author = "Andrew Watts and Terrence Kantner and Amanda Mackenzie",
year = "2011",
month = "10",
day = "12",
language = "English",
type = "Patent",
note = "EP2373675 (A2); C07K1/13",

}

TY - PAT

T1 - Thiol-Functionalising Reagents and Their Uses

AU - Watts, Andrew

AU - Kantner, Terrence

AU - Mackenzie, Amanda

PY - 2011/10/12

Y1 - 2011/10/12

N2 - Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.

AB - Reagents and methods for functionalising polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly (alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly (alkylene glycol) molecule and/or the glycan group.

M3 - Patent

M1 - EP2373675 (A2)

ER -