THERAPEUTICS

Lloyd Potter, Barry, Victor; James Dowden; Antony Galione; H Guse, Andreas; Alexander Fluegel

THERAPEUTICS

Lloyd Potter, Barry, Victor (Inventor)
, James Dowden (Inventor)
, Antony Galione (Inventor)
, H Guse, Andreas (Inventor)
, Alexander Fluegel (Inventor)

Research output: Patent

Abstract

The present invention relates to the use of a compound of formula (1) wherein: R1 comprises a carbonyl group and R2 is a hydrocarbyl group; optionally wherein said ring is further substituted; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in one or more of: modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; modulating calcium spikes in mammalian cells; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes by modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; treating diseases in one or more of brain, heart, and T-cells by modulating calcium spikes in mammalian cells.

Original language	English
Patent number	WO2007132179
IPC	A61K31/52,A61P1/18,A61P5/48,A61P9/00,G01N33/566,A61K31/452,A61K31/4523,A61P37/00,G01N33/573
Priority date	2/06/06
Publication status	Published - 22 Nov 2007

Cite this

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title = "THERAPEUTICS",

abstract = "The present invention relates to the use of a compound of formula (1) wherein: R1 comprises a carbonyl group and R2 is a hydrocarbyl group; optionally wherein said ring is further substituted; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in one or more of: modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; modulating calcium spikes in mammalian cells; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes by modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; treating diseases in one or more of brain, heart, and T-cells by modulating calcium spikes in mammalian cells.",

author = "\{Potter, Barry, Victor\}, Lloyd and James Dowden and Antony Galione and \{Guse, Andreas\}, H and Alexander Fluegel",

year = "2007",

month = nov,

day = "22",

language = "English",

type = "Patent",

note = "WO2007132179; A61K31/52,A61P1/18,A61P5/48,A61P9/00,G01N33/566,A61K31/452,A61K31/4523,A61P37/00,G01N33/573",

}

TY - PAT

T1 - THERAPEUTICS

AU - Potter, Barry, Victor, Lloyd

AU - Dowden, James

AU - Galione, Antony

AU - Guse, Andreas, H

AU - Fluegel, Alexander

PY - 2007/11/22

Y1 - 2007/11/22

N2 - The present invention relates to the use of a compound of formula (1) wherein: R1 comprises a carbonyl group and R2 is a hydrocarbyl group; optionally wherein said ring is further substituted; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in one or more of: modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; modulating calcium spikes in mammalian cells; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes by modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; treating diseases in one or more of brain, heart, and T-cells by modulating calcium spikes in mammalian cells.

AB - The present invention relates to the use of a compound of formula (1) wherein: R1 comprises a carbonyl group and R2 is a hydrocarbyl group; optionally wherein said ring is further substituted; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in one or more of: modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; modulating calcium spikes in mammalian cells; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes by modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; treating diseases in one or more of brain, heart, and T-cells by modulating calcium spikes in mammalian cells.

UR - https://worldwide.espacenet.com/patent/search/family/038624352/publication/WO2007132179A2?q=pn%3DWO2007132179A2

M3 - Patent

M1 - WO2007132179

ER -

THERAPEUTICS

Abstract

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