Therapeutics

Barry Potter (Inventor), James Dowden (Inventor), Antony Galione (Inventor), Andreas H Guse (Inventor), Fluegel Alexander (Inventor)

Research output: Patent

Abstract

The present invention relates to the use of a compound of formula (1) wherein: R1 comprises a carbonyl group and R2 is a hydrocarbyl group; optionally wherein said ring is further substituted; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in one or more of: modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; modulating calcium spikes in mammalian cells; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes by modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; treating diseases in one or more of brain, heart, and T-cells by modulating calcium spikes in mammalian cells.
Original languageEnglish
Patent numberWO2007132179 (A2)
IPCA61K31/452
Publication statusPublished - 22 Nov 2007

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Calcium Signaling
Insulin-Secreting Cells
Therapeutics
Phagocytes
T-Lymphocytes
Brain
Calcium
Salts
NAADP

Cite this

Potter, B., Dowden, J., Galione, A., Guse, A. H., & Alexander, F. (2007). IPC No. A61K31/452. Therapeutics. (Patent No. WO2007132179 (A2)).

Therapeutics. / Potter, Barry (Inventor); Dowden, James (Inventor); Galione, Antony (Inventor); Guse, Andreas H (Inventor); Alexander, Fluegel (Inventor).

IPC No.: A61K31/452. Patent No.: WO2007132179 (A2).

Research output: Patent

Potter, B, Dowden, J, Galione, A, Guse, AH & Alexander, F 2007, Therapeutics, Patent No. WO2007132179 (A2), IPC No. A61K31/452.
Potter B, Dowden J, Galione A, Guse AH, Alexander F, inventors. Therapeutics. A61K31/452. 2007 Nov 22.
Potter, Barry (Inventor) ; Dowden, James (Inventor) ; Galione, Antony (Inventor) ; Guse, Andreas H (Inventor) ; Alexander, Fluegel (Inventor). / Therapeutics. IPC No.: A61K31/452. Patent No.: WO2007132179 (A2).
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AB - The present invention relates to the use of a compound of formula (1) wherein: R1 comprises a carbonyl group and R2 is a hydrocarbyl group; optionally wherein said ring is further substituted; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in one or more of: modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; modulating calcium spikes in mammalian cells; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes; treating diseases in one or more of brain, heart, pancreatic cells (e.g. pancreatic acinar and pancreatic beta cells), immune cells, T-cells, haemopoietic cells including phagocytes by modulating the release of intracellular calcium from a store controlled by nicotinic acid adenine dinucleotide phosphate; treating diseases in one or more of brain, heart, and T-cells by modulating calcium spikes in mammalian cells.

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