Although the secondary α-deuterium kinetic isotope effect upon the degenerate SN2 reaction of chloromethane with chloride anion arises from changes in α-CH stretching force constants, α-substitution by methyl and/or methoxy groups shows this inverse inductive contribution to be approximately constant and reveals that the trend in the isotope effect (calculated by semiempirical molecular orbital theory) is determined by changes in bending force constants, in accord with the conventional view.
|Number of pages||2|
|Journal||Journal of the Chemical Society, Chemical Communications|
|Publication status||Published - 1 Dec 1993|
ASJC Scopus subject areas
- Molecular Medicine