The Wnt/beta-catenin pathway: master regulator of liver zonation?

Research output: Contribution to journalArticle

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Abstract

The liver contains two systems for the removal of ammonia-the urea cycle and the enzyme glutamine synthetase. These systems are expressed in a complementary fashion in two distinct populations of hepatocytes, referred to as periportal and perivenous cells. One of the unresolved problems in hepatology has been to elucidate the molecular mechanisms responsible for induction and maintenance of the cellular heterogeneity for ammonia detoxification. There is now a potential molecular explanation for the zonation of the urea cycle and glutamine synthetase based on the Wnt/beta-catenin pathway.
Original languageEnglish
Pages (from-to)1072-1077
Number of pages6
JournalBioessays
Volume28
Issue number11
DOIs
Publication statusPublished - Nov 2006

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Glutamate-Ammonia Ligase
beta Catenin
Ammonia
Liver
Urea
Gastroenterology
Detoxification
Hepatocytes
Maintenance
Enzymes
Population

Cite this

The Wnt/beta-catenin pathway: master regulator of liver zonation? / Burke, Z D; Tosh, D.

In: Bioessays, Vol. 28, No. 11, 11.2006, p. 1072-1077.

Research output: Contribution to journalArticle

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