Projects per year
Abstract
The liver contains two systems for the removal of ammonia-the urea cycle and the enzyme glutamine synthetase. These systems are expressed in a complementary fashion in two distinct populations of hepatocytes, referred to as periportal and perivenous cells. One of the unresolved problems in hepatology has been to elucidate the molecular mechanisms responsible for induction and maintenance of the cellular heterogeneity for ammonia detoxification. There is now a potential molecular explanation for the zonation of the urea cycle and glutamine synthetase based on the Wnt/beta-catenin pathway.
Original language | English |
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Pages (from-to) | 1072-1077 |
Number of pages | 6 |
Journal | Bioessays |
Volume | 28 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2006 |
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Dive into the research topics of 'The Wnt/beta-catenin pathway: master regulator of liver zonation?'. Together they form a unique fingerprint.Projects
- 1 Finished
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COOPERATIVE GROUP IN ORGANOGENESIS, GROWTH AND REGENERATION
Ward, A. (PI), Holman, G. (CoI), Hurst, L. (CoI), Kelsh, R. (CoI), Slack, J. (CoI) & Tosh, D. (CoI)
21/06/04 → 20/06/09
Project: Research council