TY - JOUR
T1 - The use of the velocity selective recording technique to reveal the excitation properties of the ulnar nerve in pigs
AU - Andreis, Felipe
AU - Metcalfe, Benjamin
AU - Janjua, Taha
AU - Jensen, Winnie
AU - Meijs, Suzan
AU - dos Santos Nielsen, Thomas
N1 - Funding Information:
Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 754465. The Center for Neuroplasticity and Pain is supported by the Danish National Research Foundation (DNRF121).
PY - 2021/12/23
Y1 - 2021/12/23
N2 - Decoding information from the peripheral nervous system via implantable neural interfaces remains a significant challenge, considerably limiting the advancement of neuromodulation and neuroprosthetic devices. The velocity selective recording (VSR) technique has been proposed to improve the classification of neural traffic by combining temporal and spatial information through a multi-electrode cuff (MEC). Therefore, this study investigates the feasibility of using the VSR technique to characterise fibre type based on the electrically evoked compound action potentials (eCAP) propagating along the ulnar nerve of pigs in vivo. A range of electrical stimulation parameters (amplitudes of 50 µA–10 mA and pulse durations of 100 µs, 500 µs, 1000 µs, and 5000 µs) was applied on a cutaneous and a motor branch of the ulnar nerve in nine Danish landrace pigs. Recordings were made with a 14 ring MEC and a delay-and-add algorithm was used to convert the eCAPs into the velocity domain. The results revealed two fibre populations propagating along the cutaneous branch of the ulnar nerve, with mean velocities of 55 m/s and 21 m/s, while only one dominant fibre population was found for the motor branch, with a mean velocity of 63 m/s. Because of its simplicity to provide information on the fibre selectivity and direction of propagation of nerve fibres, VSR can be implemented to advance the performance of the bidirectional control of neural prostheses and bioelectronic medicine applications.
AB - Decoding information from the peripheral nervous system via implantable neural interfaces remains a significant challenge, considerably limiting the advancement of neuromodulation and neuroprosthetic devices. The velocity selective recording (VSR) technique has been proposed to improve the classification of neural traffic by combining temporal and spatial information through a multi-electrode cuff (MEC). Therefore, this study investigates the feasibility of using the VSR technique to characterise fibre type based on the electrically evoked compound action potentials (eCAP) propagating along the ulnar nerve of pigs in vivo. A range of electrical stimulation parameters (amplitudes of 50 µA–10 mA and pulse durations of 100 µs, 500 µs, 1000 µs, and 5000 µs) was applied on a cutaneous and a motor branch of the ulnar nerve in nine Danish landrace pigs. Recordings were made with a 14 ring MEC and a delay-and-add algorithm was used to convert the eCAPs into the velocity domain. The results revealed two fibre populations propagating along the cutaneous branch of the ulnar nerve, with mean velocities of 55 m/s and 21 m/s, while only one dominant fibre population was found for the motor branch, with a mean velocity of 63 m/s. Because of its simplicity to provide information on the fibre selectivity and direction of propagation of nerve fibres, VSR can be implemented to advance the performance of the bidirectional control of neural prostheses and bioelectronic medicine applications.
KW - Compound action potential
KW - Electroneurography
KW - Multi-electrode cuff
KW - Neural recording
KW - Velocity selective recording
UR - http://www.scopus.com/inward/record.url?scp=85121560854&partnerID=8YFLogxK
U2 - 10.3390/s22010058
DO - 10.3390/s22010058
M3 - Article
AN - SCOPUS:85121560854
SN - 1424-8220
VL - 22
JO - Sensors
JF - Sensors
IS - 1
M1 - 58
ER -