The use of computational fluid dynamics in the design of a pharmaceutical processor

This study describes the use of computational fluid dynamics (CFD) in the design of a new single vessel pharmaceutical processor. Initially a simple model was developed using the computational code STAR-CD. The results of this were compared with tests carried out in a prototype processor and showed good agreement on a qualitative basis. This provided confidence to develop the design. During the design phases of the work all potential design features have been modelled and the final design choices made on the basis of the CFD results. The initial phases of the work were carried out using single-phase models, however all the recent design work has been carried out using a two-phase flow model. Agreement has been obtained between predicted and observed tests. This paper will describe the effects of vessel geometry on the performance of the processor. Future developments for the work will also be considered.