The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

Ravindra Acharya; Elizabeth Fry; David Stuart; Graham Fox; David Rowlands; Fred Brown

doi:10.1038/337709a0

The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

Ravindra Acharya, Elizabeth Fry, David Stuart, Graham Fox, David Rowlands, Fred Brown

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has important implications for cell attachment. The most immunogenic portion of the capsid, which acts as a potent peptide vaccine, forms a disordered protrusion on the virus surface.

Original language	English
Pages (from-to)	709-716
Number of pages	8
Journal	Nature
Volume	337
Issue number	6209
DOIs	https://doi.org/10.1038/337709a0
Publication status	Published - 23 Feb 1989

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General

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10.1038/337709a0

Cite this

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title = "The three-dimensional structure of foot-and-mouth disease virus at 2.9 {\AA} resolution",

abstract = "The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has important implications for cell attachment. The most immunogenic portion of the capsid, which acts as a potent peptide vaccine, forms a disordered protrusion on the virus surface.",

author = "Ravindra Acharya and Elizabeth Fry and David Stuart and Graham Fox and David Rowlands and Fred Brown",

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AU - Acharya, Ravindra

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AU - Fox, Graham

AU - Rowlands, David

AU - Brown, Fred

PY - 1989/2/23

Y1 - 1989/2/23

N2 - The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has important implications for cell attachment. The most immunogenic portion of the capsid, which acts as a potent peptide vaccine, forms a disordered protrusion on the virus surface.

AB - The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has important implications for cell attachment. The most immunogenic portion of the capsid, which acts as a potent peptide vaccine, forms a disordered protrusion on the virus surface.

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The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

Abstract

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