The thermal behaviour of enzyme activity: implications for biotechnology

R Eisenthal, M E Peterson, R M Daniel, Michael J Danson

Research output: Contribution to journalArticlepeer-review

57 Citations (SciVal)


The way that enzymes respond to temperature is fundamental to many areas of biotechnology. This has long been explained in terms of enzyme stability and catalytic activation energy, but recent observations of enzyme behaviour suggest that this picture is incomplete. We have developed and experimentally validated a new model to describe the effect of temperature on enzymes; this model incorporates additional fundamental parameters that enable a complete description of the effects of temperature on enzyme activity. In this article, we consider the biotechnological implications of this model in the areas of enzyme engineering, enzyme reactor operation and the selection and/or screening of useful enzymes from the environment.
Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalTrends in Biotechnology
Issue number7
Early online date5 Jun 2006
Publication statusPublished - 1 Jul 2006


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