The synthesis and properties of mitochondrial targeted iron chelators

Agostino Cilibrizzi; Charareh Pourzand; Vincenzo Abbate; Olivier Reelfs; Giuseppe  Floresta; Robert C Hider

doi:10.1007/s10534-022-00383-8

The synthesis and properties of mitochondrial targeted iron chelators

Agostino Cilibrizzi
, Charareh Pourzand
, Vincenzo Abbate
, Olivier Reelfs
, Giuseppe Floresta
, Robert C Hider

King's College London

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

Abstract

Iron levels in mitochondria are critically
important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in
selectively removing excess iron from mitochondria.

Original language	English
Pages (from-to)	321-337
Number of pages	17
Journal	Biometals
Volume	36
Issue number	2
Early online date	2 Apr 2022
DOIs	https://doi.org/10.1007/s10534-022-00383-8
Publication status	Published - 30 Apr 2023

Bibliographical note

Funding Information:
We wish to thank the BBSRC (Grant No. BB/J005223/1) and Parkinson’s UK (Grant No. K-1603) for the generous support of this work.

Funding

We wish to thank the BBSRC (Grant No. BB/J005223/1) and Parkinson’s UK (Grant No. K-1603) for the generous support of this work.

Keywords

Chelator synthesis
Iron chelation
Iron-probe
Mitochondria

ASJC Scopus subject areas

Biomaterials
General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences
Metals and Alloys

Access to Document

10.1007/s10534-022-00383-8Licence: CC BY

Cite this

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abstract = "Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in selectively removing excess iron from mitochondria.",

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AU - Pourzand, Charareh

AU - Abbate, Vincenzo

AU - Reelfs, Olivier

AU - Floresta , Giuseppe

AU - Hider, Robert C

N1 - Funding Information: We wish to thank the BBSRC (Grant No. BB/J005223/1) and Parkinson’s UK (Grant No. K-1603) for the generous support of this work.

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N2 - Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in selectively removing excess iron from mitochondria.

AB - Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in selectively removing excess iron from mitochondria.

KW - Chelator synthesis

KW - Iron chelation

KW - Iron-probe

KW - Mitochondria

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JO - Biometals

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IS - 2

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The synthesis and properties of mitochondrial targeted iron chelators

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Mitochondria-Targeted Iron Chelators for the Therapy of Parkinson's Disease

Mitochondrial and Lysosomal-Targeted Iron Chelators for the Monitoring and Adjustment of Cellular Labile Iron Pools

Cite this

The synthesis and properties of mitochondrial targeted iron chelators

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Mitochondria-Targeted Iron Chelators for the Therapy of Parkinson's Disease

Mitochondrial and Lysosomal-Targeted Iron Chelators for the Monitoring and Adjustment of Cellular Labile Iron Pools

Cite this