Projects per year
Abstract
Iron levels in mitochondria are critically
important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in
selectively removing excess iron from mitochondria.
important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in
selectively removing excess iron from mitochondria.
Original language | English |
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Pages (from-to) | 321-337 |
Number of pages | 17 |
Journal | Biometals |
Volume | 36 |
Early online date | 2 Apr 2022 |
DOIs | |
Publication status | Published - 30 Apr 2023 |
Bibliographical note
Funding Information:We wish to thank the BBSRC (Grant No. BB/J005223/1) and Parkinson’s UK (Grant No. K-1603) for the generous support of this work.
Funding
We wish to thank the BBSRC (Grant No. BB/J005223/1) and Parkinson’s UK (Grant No. K-1603) for the generous support of this work.
Keywords
- Chelator synthesis
- Iron chelation
- Iron-probe
- Mitochondria
ASJC Scopus subject areas
- Biomaterials
- General Biochemistry,Genetics and Molecular Biology
- General Agricultural and Biological Sciences
- Metals and Alloys
Fingerprint
Dive into the research topics of 'The synthesis and properties of mitochondrial targeted iron chelators'. Together they form a unique fingerprint.Projects
- 2 Finished
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Mitochondria-Targeted Iron Chelators for the Therapy of Parkinson's Disease
Pourzand, C. (PI) & Reelfs, O. (Researcher)
6/04/17 → 6/01/18
Project: UK charity
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Mitochondrial and Lysosomal-Targeted Iron Chelators for the Monitoring and Adjustment of Cellular Labile Iron Pools
Pourzand, C. (PI)
Biotechnology and Biological Sciences Research Council
3/04/12 → 2/04/15
Project: Research council