The synthesis and properties of mitochondrial targeted iron chelators

Agostino Cilibrizzi, Charareh Pourzand, Vincenzo Abbate, Olivier Reelfs, Giuseppe Floresta , Robert C Hider

Research output: Contribution to journalArticlepeer-review

5 Citations (SciVal)

Abstract

Iron levels in mitochondria are critically
important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in
selectively removing excess iron from mitochondria.
Original languageEnglish
Pages (from-to)321-337
Number of pages17
JournalBiometals
Volume36
Early online date2 Apr 2022
DOIs
Publication statusPublished - 30 Apr 2023

Bibliographical note

Funding Information:
We wish to thank the BBSRC (Grant No. BB/J005223/1) and Parkinson’s UK (Grant No. K-1603) for the generous support of this work.

Keywords

  • Chelator synthesis
  • Iron chelation
  • Iron-probe
  • Mitochondria

ASJC Scopus subject areas

  • Biomaterials
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Metals and Alloys

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