The synthesis and nicotinic binding activity of (+/-)-epiquinamide and (+/-)C(1)-epiepiquinamide

A Kanakubo, D Gray, N Innocent, S Wonnacott, T Gallagher

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24 Citations (SciVal)


The synthesis of (+/-)-epiquinamide 1 and (+/-)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [H-3]epibatidine binding to rat brain membranes neither (+/-)-1 nor (+/-)-2 showed any significant level of nicotinic activity. (c) 2006 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)4648-4651
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Issue number17
Publication statusPublished - Sept 2006


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