The synthesis and nicotinic binding activity of (+/-)-epiquinamide and (+/-)C(1)-epiepiquinamide

A Kanakubo, D Gray, N Innocent, S Wonnacott, T Gallagher

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Abstract

The synthesis of (+/-)-epiquinamide 1 and (+/-)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [H-3]epibatidine binding to rat brain membranes neither (+/-)-1 nor (+/-)-2 showed any significant level of nicotinic activity. (c) 2006 Elsevier Ltd. All rights reserved.
LanguageEnglish
Pages4648-4651
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume16
Issue number17
DOIs
StatusPublished - Sep 2006

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epibatidine
Rats
Assays
Brain
Membranes
epiquinamide

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The synthesis and nicotinic binding activity of (+/-)-epiquinamide and (+/-)C(1)-epiepiquinamide. / Kanakubo, A; Gray, D; Innocent, N; Wonnacott, S; Gallagher, T.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 16, No. 17, 09.2006, p. 4648-4651.

Research output: Contribution to journalArticle

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