TY - JOUR
T1 - The synthesis and nicotinic binding activity of (+/-)-epiquinamide and (+/-)C(1)-epiepiquinamide
AU - Kanakubo, A
AU - Gray, D
AU - Innocent, N
AU - Wonnacott, S
AU - Gallagher, T
PY - 2006/9
Y1 - 2006/9
N2 - The synthesis of (+/-)-epiquinamide 1 and (+/-)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [H-3]epibatidine binding to rat brain membranes neither (+/-)-1 nor (+/-)-2 showed any significant level of nicotinic activity. (c) 2006 Elsevier Ltd. All rights reserved.
AB - The synthesis of (+/-)-epiquinamide 1 and (+/-)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [H-3]epibatidine binding to rat brain membranes neither (+/-)-1 nor (+/-)-2 showed any significant level of nicotinic activity. (c) 2006 Elsevier Ltd. All rights reserved.
UR - http://dx.doi.org/10.1016/j.bmcl.2006.05.100
U2 - 10.1016/j.bmcl.2006.05.100
DO - 10.1016/j.bmcl.2006.05.100
M3 - Article
SN - 0960-894X
VL - 16
SP - 4648
EP - 4651
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 17
ER -