The structural biology of oestrogen metabolism

Mark P. Thomas, Barry V. L. Potter

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product. The reactions catalysed include aromatisation, oxidation, reduction, sulfonation, desulfonation, hydroxylation and methoxylation. The enzymes that catalyse these reactions must all recognise and bind oestrogen but, despite this, they have diverse structures. This review looks at each of these enzymes in turn, describing the structure and discussing the mechanism of the catalysed reaction. Since oestrogen has a role in many disease states inhibition of the enzymes of oestrogen metabolism may have an impact on the state or progression of the disease and inhibitors of these enzymes are briefly discussed. This article is part of a Special Issue entitled 'CSR 2013'.
Original languageEnglish
Pages (from-to)27-49
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume137
Early online date4 Jan 2013
DOIs
Publication statusPublished - 2013

Fingerprint

Metabolism
Estrogens
Enzymes
Enzyme inhibition
Aromatization
Sulfonation
Hydroxylation
Enzyme Inhibitors
Oxidation-Reduction
Disease Progression
Substrates

Cite this

The structural biology of oestrogen metabolism. / Thomas, Mark P.; Potter, Barry V. L.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 137, 2013, p. 27-49.

Research output: Contribution to journalArticle

@article{e23b9be623e74099a1b22f2507fe873f,
title = "The structural biology of oestrogen metabolism",
abstract = "Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product. The reactions catalysed include aromatisation, oxidation, reduction, sulfonation, desulfonation, hydroxylation and methoxylation. The enzymes that catalyse these reactions must all recognise and bind oestrogen but, despite this, they have diverse structures. This review looks at each of these enzymes in turn, describing the structure and discussing the mechanism of the catalysed reaction. Since oestrogen has a role in many disease states inhibition of the enzymes of oestrogen metabolism may have an impact on the state or progression of the disease and inhibitors of these enzymes are briefly discussed. This article is part of a Special Issue entitled 'CSR 2013'.",
author = "Thomas, {Mark P.} and Potter, {Barry V. L.}",
year = "2013",
doi = "10.1016/j.jsbmb.2012.12.014",
language = "English",
volume = "137",
pages = "27--49",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
issn = "0960-0760",
publisher = "Elsevier",

}

TY - JOUR

T1 - The structural biology of oestrogen metabolism

AU - Thomas, Mark P.

AU - Potter, Barry V. L.

PY - 2013

Y1 - 2013

N2 - Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product. The reactions catalysed include aromatisation, oxidation, reduction, sulfonation, desulfonation, hydroxylation and methoxylation. The enzymes that catalyse these reactions must all recognise and bind oestrogen but, despite this, they have diverse structures. This review looks at each of these enzymes in turn, describing the structure and discussing the mechanism of the catalysed reaction. Since oestrogen has a role in many disease states inhibition of the enzymes of oestrogen metabolism may have an impact on the state or progression of the disease and inhibitors of these enzymes are briefly discussed. This article is part of a Special Issue entitled 'CSR 2013'.

AB - Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product. The reactions catalysed include aromatisation, oxidation, reduction, sulfonation, desulfonation, hydroxylation and methoxylation. The enzymes that catalyse these reactions must all recognise and bind oestrogen but, despite this, they have diverse structures. This review looks at each of these enzymes in turn, describing the structure and discussing the mechanism of the catalysed reaction. Since oestrogen has a role in many disease states inhibition of the enzymes of oestrogen metabolism may have an impact on the state or progression of the disease and inhibitors of these enzymes are briefly discussed. This article is part of a Special Issue entitled 'CSR 2013'.

UR - http://www.scopus.com/inward/record.url?scp=84872777425&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1016/j.jsbmb.2012.12.014

U2 - 10.1016/j.jsbmb.2012.12.014

DO - 10.1016/j.jsbmb.2012.12.014

M3 - Article

VL - 137

SP - 27

EP - 49

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

SN - 0960-0760

ER -