The spray drying of unfractionated heparin: optimization of the operating parameters

Jagdeep Shur; Thomas G Nevell; Janis K Shute; James R Smith

doi:10.1080/03639040701657552

The spray drying of unfractionated heparin: optimization of the operating parameters

Jagdeep Shur, Thomas G Nevell, Janis K Shute, James R Smith

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

Abstract

Unfractionated heparin is an anti-inflammatory mucoactive agent, with the potential to treat the inflamed and mucus-obstructed airways in patients with cystic fibrosis. In this study, unfractionated heparin has been spray-dried to produce spherical micronized particles in the size range 1-5 microm, which is suitable for delivery by dry-powder inhalation. Spray drying parameters have been optimized using a 2(4) factorial experimental design. The feed concentration and atomization spray flow rate have the greatest effects on recovery (typically 60%) and particle size.

Original language	English
Pages (from-to)	559-68
Number of pages	10
Journal	Drug Development and Industrial Pharmacy
Volume	34
Issue number	6
DOIs	https://doi.org/10.1080/03639040701657552
Publication status	Published - Jun 2008

Keywords

Administration, Inhalation
Aerosols
Calorimetry, Differential Scanning
Cystic Fibrosis
Heparin
Microscopy, Electron, Scanning
Particle Size
Powders

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10.1080/03639040701657552

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title = "The spray drying of unfractionated heparin: optimization of the operating parameters",

abstract = "Unfractionated heparin is an anti-inflammatory mucoactive agent, with the potential to treat the inflamed and mucus-obstructed airways in patients with cystic fibrosis. In this study, unfractionated heparin has been spray-dried to produce spherical micronized particles in the size range 1-5 microm, which is suitable for delivery by dry-powder inhalation. Spray drying parameters have been optimized using a 2(4) factorial experimental design. The feed concentration and atomization spray flow rate have the greatest effects on recovery (typically 60%) and particle size.",

keywords = "Administration, Inhalation, Aerosols, Calorimetry, Differential Scanning, Cystic Fibrosis, Heparin, Microscopy, Electron, Scanning, Particle Size, Powders",

author = "Jagdeep Shur and Nevell, {Thomas G} and Shute, {Janis K} and Smith, {James R}",

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T2 - optimization of the operating parameters

AU - Shur, Jagdeep

AU - Nevell, Thomas G

AU - Shute, Janis K

AU - Smith, James R

PY - 2008/6

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AB - Unfractionated heparin is an anti-inflammatory mucoactive agent, with the potential to treat the inflamed and mucus-obstructed airways in patients with cystic fibrosis. In this study, unfractionated heparin has been spray-dried to produce spherical micronized particles in the size range 1-5 microm, which is suitable for delivery by dry-powder inhalation. Spray drying parameters have been optimized using a 2(4) factorial experimental design. The feed concentration and atomization spray flow rate have the greatest effects on recovery (typically 60%) and particle size.

KW - Administration, Inhalation

KW - Aerosols

KW - Calorimetry, Differential Scanning

KW - Cystic Fibrosis

KW - Heparin

KW - Microscopy, Electron, Scanning

KW - Particle Size

KW - Powders

UR - http://dx.doi.org/10.1080/03639040701657552

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DO - 10.1080/03639040701657552

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SN - 0363-9045

VL - 34

SP - 559

EP - 568

JO - Drug Development and Industrial Pharmacy

JF - Drug Development and Industrial Pharmacy

IS - 6

ER -

The spray drying of unfractionated heparin: optimization of the operating parameters

Abstract

Keywords

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