The spray drying of unfractionated heparin

optimization of the operating parameters

Jagdeep Shur, Thomas G Nevell, Janis K Shute, James R Smith

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Unfractionated heparin is an anti-inflammatory mucoactive agent, with the potential to treat the inflamed and mucus-obstructed airways in patients with cystic fibrosis. In this study, unfractionated heparin has been spray-dried to produce spherical micronized particles in the size range 1-5 microm, which is suitable for delivery by dry-powder inhalation. Spray drying parameters have been optimized using a 2(4) factorial experimental design. The feed concentration and atomization spray flow rate have the greatest effects on recovery (typically 60%) and particle size.

Original languageEnglish
Pages (from-to)559-68
Number of pages10
JournalDrug Development and Industrial Pharmacy
Volume34
Issue number6
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Spray drying
Particle Size
Heparin
Atomization
Mucus
Cystic Fibrosis
Powders
Design of experiments
Inhalation
Anti-Inflammatory Agents
Research Design
Particle size
Flow rate
Recovery

Keywords

  • Administration, Inhalation
  • Aerosols
  • Calorimetry, Differential Scanning
  • Cystic Fibrosis
  • Heparin
  • Microscopy, Electron, Scanning
  • Particle Size
  • Powders

Cite this

The spray drying of unfractionated heparin : optimization of the operating parameters. / Shur, Jagdeep; Nevell, Thomas G; Shute, Janis K; Smith, James R.

In: Drug Development and Industrial Pharmacy, Vol. 34, No. 6, 06.2008, p. 559-68.

Research output: Contribution to journalArticle

Shur, Jagdeep ; Nevell, Thomas G ; Shute, Janis K ; Smith, James R. / The spray drying of unfractionated heparin : optimization of the operating parameters. In: Drug Development and Industrial Pharmacy. 2008 ; Vol. 34, No. 6. pp. 559-68.
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