The spray drying of unfractionated heparin: optimization of the operating parameters

Jagdeep Shur, Thomas G Nevell, Janis K Shute, James R Smith

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Unfractionated heparin is an anti-inflammatory mucoactive agent, with the potential to treat the inflamed and mucus-obstructed airways in patients with cystic fibrosis. In this study, unfractionated heparin has been spray-dried to produce spherical micronized particles in the size range 1-5 microm, which is suitable for delivery by dry-powder inhalation. Spray drying parameters have been optimized using a 2(4) factorial experimental design. The feed concentration and atomization spray flow rate have the greatest effects on recovery (typically 60%) and particle size.

Original languageEnglish
Pages (from-to)559-68
Number of pages10
JournalDrug Development and Industrial Pharmacy
Volume34
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Administration, Inhalation
  • Aerosols
  • Calorimetry, Differential Scanning
  • Cystic Fibrosis
  • Heparin
  • Microscopy, Electron, Scanning
  • Particle Size
  • Powders

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