The spark of life: electricity and regeneration

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6 Citations (Scopus)

Abstract

A recent paper shows that a proton pump, the vacuolar-type adenosine triphosphatase (V-ATPase), is necessary for Xenopus tadpole tail regeneration. The V-ATPase is synthesized in distal cells of the regeneration bud as an early response to amputation, and its role in regeneration is specifically to pump H+ out of cells. Although the downstream effects of proton movement are not known, they may be mediated through changes in membrane potential. This work could reopen a consideration of the role of electric fields in regeneration, an issue that has caused much controversy in the past.
Original languageEnglish
Pages (from-to)pe54
JournalScience STKE
Volume2007
Issue number405
DOIs
Publication statusPublished - 25 Sep 2007

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