TY - JOUR
T1 - The spark of life
T2 - electricity and regeneration
AU - Slack, Jonathan M. W.
PY - 2007/9/25
Y1 - 2007/9/25
N2 - A recent paper shows that a proton pump, the vacuolar-type adenosine triphosphatase (V-ATPase), is necessary for Xenopus tadpole tail regeneration. The V-ATPase is synthesized in distal cells of the regeneration bud as an early response to amputation, and its role in regeneration is specifically to pump H+ out of cells. Although the downstream effects of proton movement are not known, they may be mediated through changes in membrane potential. This work could reopen a consideration of the role of electric fields in regeneration, an issue that has caused much controversy in the past.
AB - A recent paper shows that a proton pump, the vacuolar-type adenosine triphosphatase (V-ATPase), is necessary for Xenopus tadpole tail regeneration. The V-ATPase is synthesized in distal cells of the regeneration bud as an early response to amputation, and its role in regeneration is specifically to pump H+ out of cells. Although the downstream effects of proton movement are not known, they may be mediated through changes in membrane potential. This work could reopen a consideration of the role of electric fields in regeneration, an issue that has caused much controversy in the past.
UR - http://dx.doi.org/10.1126/stke.4052007pe54
UR - http://stke.sciencemag.org/content/2007/405/pe54.abstract
U2 - 10.1126/stke.4052007pe54
DO - 10.1126/stke.4052007pe54
M3 - Article
VL - 2007
SP - pe54
JO - Science STKE
JF - Science STKE
IS - 405
ER -