Abstract
While the average human life span continues to increase, there is little evidence that this is leading to a contemporaneous increase in "healthy years" experienced by our aging population. Consequently, many scientists focus their research on understanding the process of aging and trialing interventions that can promote healthspan. The 2021 Midwest Aging Consortium consensus statement is to develop and further the understanding of aging and age-related disease using the wealth of expertise across universities in the Midwestern United States. This report summarizes the cutting-edge research covered in a virtual symposium held by a consortium of researchers in the Midwestern United States, spanning topics such as senescence biomarkers, serotonin-induced DNA protection, immune system development, multisystem impacts of aging, neural decline following severe infection, the unique transcriptional impact of calorie restriction of different fat depots, the pivotal role of fasting in calorie restriction, the impact of peroxisome dysfunction, and the influence of early life trauma on health. The symposium speakers presented data from studies conducted in a variety of common laboratory animals as well as less-common species, including Caenorhabditis elegans, Drosophila, mice, rhesus macaques, elephants, and humans. The consensus of the symposium speakers is that this consortium highlights the strength of aging research in the Midwestern United States as well as the benefits of a collaborative and diverse approach to geroscience.
| Original language | English |
|---|---|
| Pages (from-to) | 2156-2161 |
| Number of pages | 6 |
| Journal | Journal of Gerontology: series A - Medical Sciences |
| Volume | 76 |
| Issue number | 12 |
| Early online date | 29 Jul 2021 |
| DOIs | |
| Publication status | Published - 15 Nov 2021 |
Acknowledgements
We would like to thank Drs. Rozalyn Anderson, Paul Robbins, and Laura Nidernhofer for their role in the establishment of the Midwest Aging Consortium and their contributions to this meeting as well as this report. In addition, we would like to thank the Glenn Foundation for Medical Research for their support of Aging Science Talks, which hosted this meeting.Funding
C.L.G. is supported by a Glenn Foundation for Medical Research Postdoctoral Fellowship in Aging Research. M.J.Y. is supported by the Irene Diamond Fund/American Federation for Aging Research Postdoctoral Transition Award. H.H.P. is supported by an National Institute on Aging F31 Predoctoral Fellowship (NIA F31 AG066311). D.W.L. and the Lamming laboratory are supported in part by research grants and funds from the National Institutes of Health (NIH; AG056771 and AG062328), the University of Wisconsin–Madison School of Medicine and Public Health and Department of Medicine, and the United States Department of Veterans Affairs (I01-BX004031). D.E.C. is supported by the Morris Animal Foundation postdoctoral fellowship and her research in part by grants and funds from the NIH (P30 AG050886), Indiana Clinical and Translational Sciences Institute, and Animal Models for the Social Dimensions of Health and Aging Research Network (R24 AG065172). D.A.E. is supported by the Mayo Clinic T32 Research on Aging Training Program (T32AG049672). J.C. has received support from the T32 Biology of Aging Program (T32 AG000213). P.L. and the Bai laboratory are supported by the NIH/NIA R01AG058741. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work does not represent the views of the Department of Veterans Affairs or the US Government.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Aging
- Animals
- Biomedical Research/trends
- Caloric Restriction
- Geroscience/trends
- Humans
- Longevity
- Macaca mulatta
- Models, Animal
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