The Role of PI3K Isoforms in Autoimmune Disease

Stephen G. Ward

doi:10.1007/978-3-031-06566-8_14

The Role of PI3K Isoforms in Autoimmune Disease

Stephen G. Ward

Department of Pharmacy and Pharmacology and Bath Centre for Therapeutic Innovation

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

3 Citations (SciVal)

Abstract

Aberrant overactivation of the immune system can give rise to chronic and persistent self-attack, culminating in autoimmune disease. This is currently managed therapeutically using potent immunosuppressive and anti-inflammatory drugs. Class I phosphoinositide-3-kinases (PI3Ks) have been identified as ideal therapeutic targets for autoimmune diseases given their wide-ranging roles in immunological processes. Although progress has been hampered by issues such as poor drug tolerance and drug resistance, several PI3K inhibitors have now received regulatory approval with many others in development, including several intended to suppress the immune response in autoimmune and inflammatory diseases. This chapter reviews the evidence for contribution of aberrant PI3K activity to a range of autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and type I diabetes) and possible therapeutic application of isoform-specific PI3K inhibitors as immunosuppressive drugs.

Original language	English
Title of host publication	Current Topics in Microbiology and Immunology
Editors	M. Dominguez-Villar
Place of Publication	Cham, Switzerland
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	337-347
Number of pages	11
ISBN (Electronic)	9783031065668
ISBN (Print)	9783031065651
DOIs	https://doi.org/10.1007/978-3-031-06566-8_14
Publication status	Published - 16 Oct 2022

Publication series

Name	Current Topics in Microbiology and Immunology
Volume	436
ISSN (Print)	0070-217X
ISSN (Electronic)	2196-9965

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Arthritis
Autoimmune
Diabetes
Inhibitors
Leukocytes
Lupus
Multiple Sclerosis
PI3K

ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)

Access to Document

10.1007/978-3-031-06566-8_14

Cite this

The Role of PI3K Isoforms in Autoimmune Disease. / Ward, Stephen G.
Current Topics in Microbiology and Immunology. ed. / M. Dominguez-Villar. Cham, Switzerland: Springer Science and Business Media Deutschland GmbH, 2022. p. 337-347 (Current Topics in Microbiology and Immunology; Vol. 436).

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

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The Role of PI3K Isoforms in Autoimmune Disease

Abstract

Publication series

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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