TY - JOUR
T1 - The role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study
AU - Brown, Victoria L
AU - White, K A Jane
PY - 2011/6
Y1 - 2011/6
N2 - Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. We find that the vaccination of sexually active individuals has a greater impact on disease control than the vaccination of sexually non-active individuals. Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state.
AB - Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. We find that the vaccination of sexually active individuals has a greater impact on disease control than the vaccination of sexually non-active individuals. Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state.
KW - mathematical model
KW - public health policy
KW - sexually transmitted infection
UR - http://www.scopus.com/inward/record.url?scp=79954908956&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1016/j.mbs.2011.02.009
U2 - 10.1016/j.mbs.2011.02.009
DO - 10.1016/j.mbs.2011.02.009
M3 - Article
SN - 0025-5564
VL - 231
SP - 126
EP - 134
JO - Mathematical Biosciences
JF - Mathematical Biosciences
IS - 2
ER -
