The role of optimal control in assessing the most cost-effective implementation of a vaccination programme: HPV as a case study

Victoria L Brown, K A Jane White

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. We find that the vaccination of sexually active individuals has a greater impact on disease control than the vaccination of sexually non-active individuals. Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state.
Original languageEnglish
Pages (from-to)126-134
Number of pages9
JournalMathematical Biosciences
Volume231
Issue number2
Early online date4 Mar 2011
DOIs
Publication statusPublished - Jun 2011

Keywords

  • mathematical model
  • public health policy
  • sexually transmitted infection

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