The role of B. pertussis vaccine antigen gene variants in pertussis resurgence and possible consequences for vaccine development

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Abstract

Whooping cough, or pertussis, caused by Bordetella pertussis is considered resurgent in a number of countries world-wide, despite continued high level vaccine coverage. Among a number of causes for this that have been proposed, is the emergence of B. pertussis strains expressing variants of the antigens contained in acellular pertussis vaccines; i.e. the evolution of B. pertussis towards vaccine escape. This commentary highlights the contradictory nature of evidence for this but also discusses the importance of understanding the role of B. pertussis adaptation to vaccine-mediated immune selection pressures for vaccine-mediated pertussis control strategies.

Original languageEnglish
Pages (from-to)1274-1276
JournalHuman Vaccines and Immunotherapeutics
Volume12
Issue number5
Early online date18 Feb 2016
DOIs
Publication statusPublished - 2016

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