The Relationship of p Ka and Acute Skin Irritation in Man

Bret Berner; Donald R. Wilson; Richard H. Guy; Gerard C. Mazzenga; Frank H. Clarke; Howard I. Maibach

doi:10.1023/A:1015931105660

The Relationship of p K_a and Acute Skin Irritation in Man

Bret Berner, Donald R. Wilson, Richard H. Guy, Gerard C. Mazzenga, Frank H. Clarke, Howard I. Maibach

Research output: Contribution to journal › Article › peer-review

Abstract

The relationship between p K_a and skin irritation in man is studied for a homologous series of benzoic acid derivatives, which permeate through human skin at comparable rates (15–88 µg/cm²/hr). Skin irritation and p K_a are correlated for p K_a ≤ 4. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to p K_a, erythema at 24 hr appears to be the most sensitive parameter to variation in p K_a when p K_a ≤ 4.

Original language	English
Pages (from-to)	660-663
Number of pages	4
Journal	Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Volume	5
Issue number	10
DOIs	https://doi.org/10.1023/A:1015931105660
Publication status	Published - 31 Oct 1988

Keywords

chemical structure/irritation
p K
pH, skin permeation
skin irritation

ASJC Scopus subject areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

Access to Document

10.1023/A:1015931105660

Cite this

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AU - Clarke, Frank H.

AU - Maibach, Howard I.

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