The Relationship of p Ka and Acute Skin Irritation in Man

Bret Berner, Donald R. Wilson, Richard H. Guy, Gerard C. Mazzenga, Frank H. Clarke, Howard I. Maibach

Research output: Contribution to journalArticlepeer-review


The relationship between p Ka and skin irritation in man is studied for a homologous series of benzoic acid derivatives, which permeate through human skin at comparable rates (15–88 µg/cm2/hr). Skin irritation and p Ka are correlated for p Ka ≤ 4. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to p Ka, erythema at 24 hr appears to be the most sensitive parameter to variation in p Ka when p Ka ≤ 4.

Original languageEnglish
Pages (from-to)660-663
Number of pages4
JournalPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Issue number10
Publication statusPublished - 31 Oct 1988


  • chemical structure/irritation
  • p K
  • pH, skin permeation
  • skin irritation

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)


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