The relationship between poly(lactide-co-glycolide) monomer ratio, molecular weight and hollow fibre membrane scaffold morphology

Marianne J Ellis, Julian B Chaudhuri

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Abstract

The morphological characteristics of hollow fibre membrane scaffolds are fundamental to their use for cell culture in regenerative medicine applications. This paper evaluates the morphologies of hollow fibre membrane scaffolds fabricated from six commercial poly(lactide-co-glycolide) (PLGA) polymers with lactide: glycolide (PLA: PGA) molar ratios of 45:55, 50:50, 65:35, 75:25, 85:15 and 100:0. For polymers 65:35 to 100:0 (weight-averaged molecular weight, Mw = 109-124 kDa), viscosity and effective porosity were inversely proportional to PLA content; surface roughness was proportional to PLA content and no conclusive trend was seen with outer skin thickness or mean pore size. 50:50 (Mw = 74 kDa) did not fit these trends while 45:55 (Mw = 12 kDa) was too inviscid to form a membrane. Effective porosity was also seen to be proportional to the polydispersity index (PDI). Further studies are required to investigate how the polymer properties at the molecular scale, i.e. transesterification and tacticity affect the membrane characteristics. The Mw, PLA: PGA ratio and PDI are key factors which can be selected to obtain the desired PLGA membrane morphology.
Original languageEnglish
Pages (from-to)832-839
Number of pages8
JournalAsia-Pacific Journal of Chemical Engineering
Volume6
Issue number6
DOIs
Publication statusPublished - Nov 2011

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Polyglactin 910
Scaffolds
Monomers
Molecular weight
membrane
Membranes
Fibers
Prostaglandins A
Polymers
polymer
Polydispersity
Porosity
porosity
Transesterification
Scaffolds (biology)
surface roughness
Cell culture
medicine
Pore size
skin

Cite this

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title = "The relationship between poly(lactide-co-glycolide) monomer ratio, molecular weight and hollow fibre membrane scaffold morphology",
abstract = "The morphological characteristics of hollow fibre membrane scaffolds are fundamental to their use for cell culture in regenerative medicine applications. This paper evaluates the morphologies of hollow fibre membrane scaffolds fabricated from six commercial poly(lactide-co-glycolide) (PLGA) polymers with lactide: glycolide (PLA: PGA) molar ratios of 45:55, 50:50, 65:35, 75:25, 85:15 and 100:0. For polymers 65:35 to 100:0 (weight-averaged molecular weight, Mw = 109-124 kDa), viscosity and effective porosity were inversely proportional to PLA content; surface roughness was proportional to PLA content and no conclusive trend was seen with outer skin thickness or mean pore size. 50:50 (Mw = 74 kDa) did not fit these trends while 45:55 (Mw = 12 kDa) was too inviscid to form a membrane. Effective porosity was also seen to be proportional to the polydispersity index (PDI). Further studies are required to investigate how the polymer properties at the molecular scale, i.e. transesterification and tacticity affect the membrane characteristics. The Mw, PLA: PGA ratio and PDI are key factors which can be selected to obtain the desired PLGA membrane morphology.",
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AB - The morphological characteristics of hollow fibre membrane scaffolds are fundamental to their use for cell culture in regenerative medicine applications. This paper evaluates the morphologies of hollow fibre membrane scaffolds fabricated from six commercial poly(lactide-co-glycolide) (PLGA) polymers with lactide: glycolide (PLA: PGA) molar ratios of 45:55, 50:50, 65:35, 75:25, 85:15 and 100:0. For polymers 65:35 to 100:0 (weight-averaged molecular weight, Mw = 109-124 kDa), viscosity and effective porosity were inversely proportional to PLA content; surface roughness was proportional to PLA content and no conclusive trend was seen with outer skin thickness or mean pore size. 50:50 (Mw = 74 kDa) did not fit these trends while 45:55 (Mw = 12 kDa) was too inviscid to form a membrane. Effective porosity was also seen to be proportional to the polydispersity index (PDI). Further studies are required to investigate how the polymer properties at the molecular scale, i.e. transesterification and tacticity affect the membrane characteristics. The Mw, PLA: PGA ratio and PDI are key factors which can be selected to obtain the desired PLGA membrane morphology.

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