The relationship between pKa and skin irritation for a series of basic penetrants in man

Bret Berner; Donald R. Wilson; Robert J. Steffens; Gerard C. Mazzenga; Robert Hinz; Richard H. Guy; Howard I. Maibach

doi:10.1093/toxsci/15.4.760

The relationship between pK_a and skin irritation for a series of basic penetrants in man

Bret Berner, Donald R. Wilson, Robert J. Steffens, Gerard C. Mazzenga, Robert Hinz, Richard H. Guy, Howard I. Maibach

Research output: Contribution to journal › Article › peer-review

Abstract

The Relationship between pK_a and Skin Irritation for a Series of Basic Penetrants in Man. BERNER, B., WILSON, D. R., STEFFENS, R. J., MAZZENGA, G. C., HINZ, R., GUY, R. H., AND MAIBACH, H. I. (1990). Fundam. Appl. Toxicol 15, 760-766. For a series of bases, which penetrate through human skin in vitro at similar rates (0.056-0.49 μM/cm²/hr), penetrant pK_a is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a pK_a > 8. The irritation potential of acids with pK_a ≤ 4 has been previously reported; pK_a appears highly predictive of acute skin irritation for acids and bases in man.

Original language	English
Pages (from-to)	760-766
Number of pages	7
Journal	Toxicological Sciences
Volume	15
Issue number	4
DOIs	https://doi.org/10.1093/toxsci/15.4.760
Publication status	Published - 30 Nov 1990

Bibliographical note

Funding Information:
’ To whom correspondence should be addressed. 2 Supported in part by a Cooperative Agreement (CR-8 12474) with the U.S. Environmental Protection Agency.

Funding

’ To whom correspondence should be addressed. 2 Supported in part by a Cooperative Agreement (CR-8 12474) with the U.S. Environmental Protection Agency.

ASJC Scopus subject areas

Toxicology

Access to Document

10.1093/toxsci/15.4.760

Cite this

@article{ce674a97166046bf8710893a921dd7f0,

title = "The relationship between pKa and skin irritation for a series of basic penetrants in man",

abstract = "The Relationship between pKa and Skin Irritation for a Series of Basic Penetrants in Man. BERNER, B., WILSON, D. R., STEFFENS, R. J., MAZZENGA, G. C., HINZ, R., GUY, R. H., AND MAIBACH, H. I. (1990). Fundam. Appl. Toxicol 15, 760-766. For a series of bases, which penetrate through human skin in vitro at similar rates (0.056-0.49 μM/cm2/hr), penetrant pKa is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a pKa > 8. The irritation potential of acids with pKa ≤ 4 has been previously reported; pKa appears highly predictive of acute skin irritation for acids and bases in man.",

author = "Bret Berner and Wilson, {Donald R.} and Steffens, {Robert J.} and Mazzenga, {Gerard C.} and Robert Hinz and Guy, {Richard H.} and Maibach, {Howard I.}",

note = "Funding Information: {\textquoteright} To whom correspondence should be addressed. 2 Supported in part by a Cooperative Agreement (CR-8 12474) with the U.S. Environmental Protection Agency.",

year = "1990",

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AU - Hinz, Robert

AU - Guy, Richard H.

AU - Maibach, Howard I.

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N2 - The Relationship between pKa and Skin Irritation for a Series of Basic Penetrants in Man. BERNER, B., WILSON, D. R., STEFFENS, R. J., MAZZENGA, G. C., HINZ, R., GUY, R. H., AND MAIBACH, H. I. (1990). Fundam. Appl. Toxicol 15, 760-766. For a series of bases, which penetrate through human skin in vitro at similar rates (0.056-0.49 μM/cm2/hr), penetrant pKa is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a pKa > 8. The irritation potential of acids with pKa ≤ 4 has been previously reported; pKa appears highly predictive of acute skin irritation for acids and bases in man.

AB - The Relationship between pKa and Skin Irritation for a Series of Basic Penetrants in Man. BERNER, B., WILSON, D. R., STEFFENS, R. J., MAZZENGA, G. C., HINZ, R., GUY, R. H., AND MAIBACH, H. I. (1990). Fundam. Appl. Toxicol 15, 760-766. For a series of bases, which penetrate through human skin in vitro at similar rates (0.056-0.49 μM/cm2/hr), penetrant pKa is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a pKa > 8. The irritation potential of acids with pKa ≤ 4 has been previously reported; pKa appears highly predictive of acute skin irritation for acids and bases in man.

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