TY - JOUR
T1 - The relationship between pKa and skin irritation for a series of basic penetrants in man
AU - Berner, Bret
AU - Wilson, Donald R.
AU - Steffens, Robert J.
AU - Mazzenga, Gerard C.
AU - Hinz, Robert
AU - Guy, Richard H.
AU - Maibach, Howard I.
N1 - Funding Information:
’ To whom correspondence should be addressed. 2 Supported in part by a Cooperative Agreement (CR-8 12474) with the U.S. Environmental Protection Agency.
PY - 1990/11/30
Y1 - 1990/11/30
N2 - The Relationship between pKa and Skin Irritation for a Series of Basic Penetrants in Man. BERNER, B., WILSON, D. R., STEFFENS, R. J., MAZZENGA, G. C., HINZ, R., GUY, R. H., AND MAIBACH, H. I. (1990). Fundam. Appl. Toxicol 15, 760-766. For a series of bases, which penetrate through human skin in vitro at similar rates (0.056-0.49 μM/cm2/hr), penetrant pKa is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a pKa > 8. The irritation potential of acids with pKa ≤ 4 has been previously reported; pKa appears highly predictive of acute skin irritation for acids and bases in man.
AB - The Relationship between pKa and Skin Irritation for a Series of Basic Penetrants in Man. BERNER, B., WILSON, D. R., STEFFENS, R. J., MAZZENGA, G. C., HINZ, R., GUY, R. H., AND MAIBACH, H. I. (1990). Fundam. Appl. Toxicol 15, 760-766. For a series of bases, which penetrate through human skin in vitro at similar rates (0.056-0.49 μM/cm2/hr), penetrant pKa is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a pKa > 8. The irritation potential of acids with pKa ≤ 4 has been previously reported; pKa appears highly predictive of acute skin irritation for acids and bases in man.
UR - http://www.scopus.com/inward/record.url?scp=77957176944&partnerID=8YFLogxK
U2 - 10.1093/toxsci/15.4.760
DO - 10.1093/toxsci/15.4.760
M3 - Article
C2 - 2086317
AN - SCOPUS:77957176944
VL - 15
SP - 760
EP - 766
JO - Toxicological Sciences
JF - Toxicological Sciences
SN - 1096-6080
IS - 4
ER -