The providential randomisation of genotypes

Jean Baptiste Pingault; Pasco Fearon; Essi Viding; Neil Davies; Marcus R. Munafò; George Davey Smith

doi:10.1017/S0140525X2200214X

The providential randomisation of genotypes

Jean Baptiste Pingault, Pasco Fearon, Essi Viding, Neil Davies, Marcus R. Munafò, George Davey Smith

Vice Chancellor's Office

Research output: Contribution to journal › Review article › peer-review

Abstract

When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.

Original language	English
Article number	e197
Journal	Behavioral and Brain Sciences
Volume	46
Early online date	11 Sept 2023
DOIs	https://doi.org/10.1017/S0140525X2200214X
Publication status	Published - 11 Sept 2023

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Physiology
Behavioral Neuroscience

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10.1017/S0140525X2200214X

https://research-information.bris.ac.uk/en/publications/the-providential-randomisation-of-genotypesLicence: CC BY-NC-ND

Cite this

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title = "The providential randomisation of genotypes",

abstract = "When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.",

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AU - Fearon, Pasco

AU - Viding, Essi

AU - Davies, Neil

AU - Munafò, Marcus R.

AU - Davey Smith, George

PY - 2023/9/11

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N2 - When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.

AB - When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.

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DO - 10.1017/S0140525X2200214X

M3 - Review article

C2 - 37694914

AN - SCOPUS:85170483039

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VL - 46

JO - Behavioral and Brain Sciences

JF - Behavioral and Brain Sciences

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The providential randomisation of genotypes

Abstract

ASJC Scopus subject areas

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