The prediction of plasma levels of drugs following transdermal application

Richard H. Guy; Jonathan Hadgraft

doi:10.1016/0168-3659(85)90015-X

The prediction of plasma levels of drugs following transdermal application

Research output: Contribution to journal › Article › peer-review

Abstract

A theoretical description of transdermal drug delivery has been developed using a straight-forward linear pharmacokinetic model. However, the rate constants in this model have been chosen such that they may be related to the physicochemical properties of the penetrant. Thus equations have been derived which may be used predictively to estimate the concentrations of drug in the plasma following transdermal application. The theoretical model has been used to predict plasma levels of scopolamine after this drug has been applied to the skin surface in a device that releases with zero order kinetics.

Original language	English
Pages (from-to)	177-182
Number of pages	6
Journal	Journal of Controlled Release
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/0168-3659(85)90015-X
Publication status	Published - Apr 1985

Bibliographical note

Funding Information:
We would like to thank the Wellcome Trust and the Burroughs Wellcome Fund for travel grants and Vick International for financial support.

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/0168-3659(85)90015-X

Cite this

@article{9273306f3f3d484f86e593c16a6b0bd8,

title = "The prediction of plasma levels of drugs following transdermal application",

abstract = "A theoretical description of transdermal drug delivery has been developed using a straight-forward linear pharmacokinetic model. However, the rate constants in this model have been chosen such that they may be related to the physicochemical properties of the penetrant. Thus equations have been derived which may be used predictively to estimate the concentrations of drug in the plasma following transdermal application. The theoretical model has been used to predict plasma levels of scopolamine after this drug has been applied to the skin surface in a device that releases with zero order kinetics.",

author = "Guy, {Richard H.} and Jonathan Hadgraft",

note = "Funding Information: We would like to thank the Wellcome Trust and the Burroughs Wellcome Fund for travel grants and Vick International for financial support.",

year = "1985",

month = apr,

doi = "10.1016/0168-3659(85)90015-X",

language = "English",

volume = "1",

pages = "177--182",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - The prediction of plasma levels of drugs following transdermal application

AU - Guy, Richard H.

AU - Hadgraft, Jonathan

N1 - Funding Information: We would like to thank the Wellcome Trust and the Burroughs Wellcome Fund for travel grants and Vick International for financial support.

PY - 1985/4

Y1 - 1985/4

N2 - A theoretical description of transdermal drug delivery has been developed using a straight-forward linear pharmacokinetic model. However, the rate constants in this model have been chosen such that they may be related to the physicochemical properties of the penetrant. Thus equations have been derived which may be used predictively to estimate the concentrations of drug in the plasma following transdermal application. The theoretical model has been used to predict plasma levels of scopolamine after this drug has been applied to the skin surface in a device that releases with zero order kinetics.

AB - A theoretical description of transdermal drug delivery has been developed using a straight-forward linear pharmacokinetic model. However, the rate constants in this model have been chosen such that they may be related to the physicochemical properties of the penetrant. Thus equations have been derived which may be used predictively to estimate the concentrations of drug in the plasma following transdermal application. The theoretical model has been used to predict plasma levels of scopolamine after this drug has been applied to the skin surface in a device that releases with zero order kinetics.

UR - http://www.scopus.com/inward/record.url?scp=0021794427&partnerID=8YFLogxK

U2 - 10.1016/0168-3659(85)90015-X

DO - 10.1016/0168-3659(85)90015-X

M3 - Article

AN - SCOPUS:0021794427

SN - 0168-3659

VL - 1

SP - 177

EP - 182

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 3

ER -

The prediction of plasma levels of drugs following transdermal application

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this