The potential of polymeric film-forming systems as sustained delivery platforms for topical drugs

Kit Frederiksen, Richard H. Guy, Karsten Petersson

Research output: Contribution to journalArticle

13 Citations (Scopus)
134 Downloads (Pure)

Abstract

Introduction: Dosing regimens requiring multiple daily applications frequently result in poor patient compliance, especially in the treatment of chronic skin diseases. Consequently, development of sustained delivery systems for topical drugs permitting less frequent dosing is of continuing interest for dermatological therapy. Areas covered: This potential of polymeric film-forming systems (FFS), created in situ on the skin, as sustained delivery platforms for topical drug delivery is reviewed. Key formulation parameters that determine delivery efficiency are considered focussing on those that permit a drug reservoir to be established in the upper layers of the skin and/or on the skin surface from which release can be sustained over a prolonged period. The advantageous and superior cosmetic attributes of FFS (compared to conventional semi-solid formulations) that offer significantly improved patient compliance are also addressed. Expert opinion: The promise of polymeric FFS as convenient and aesthetic platforms for sustained topical drug delivery is clear. Manipulation of the formulation allows the delivery profile to be customized and optimized to take advantage of both a rapid, initial input of drug into the skin (likely due to a transient period of supersaturation) and a slower, controlled release over an extended time from the residual film created thereafter.

Original languageEnglish
Pages (from-to)349-360
JournalExpert Opinion on Drug Delivery
Volume13
Issue number3
Early online date18 Dec 2015
DOIs
Publication statusPublished - 2016

Fingerprint

Skin
Patient Compliance
Pharmaceutical Preparations
Expert Testimony
Drug Delivery Systems
Esthetics
Skin Diseases
Cosmetics
Chronic Disease
Therapeutics

Keywords

  • Dermal drug delivery
  • polymeric film-forming systems
  • supersaturation
  • sustained delivery
  • topical formulations

Cite this

The potential of polymeric film-forming systems as sustained delivery platforms for topical drugs. / Frederiksen, Kit; Guy, Richard H.; Petersson, Karsten.

In: Expert Opinion on Drug Delivery, Vol. 13, No. 3, 2016, p. 349-360.

Research output: Contribution to journalArticle

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