The potential of magnetic hyperthermia for triggering the differentiation of cancer cells

Sandhya Moise, James M. Byrne, Alicia J. El Haj, Neil D. Telling

Research output: Contribution to journalArticle

14 Citations (Scopus)
43 Downloads (Pure)

Abstract

Magnetic hyperthermia is a potential technique for cancer therapy that exploits heat generated by magnetic nanoparticles to kill cancerous cells. Many studies have shown that magnetic hyperthermia is effective at killing cancer cells both in vitro and in vivo, however little attention has been paid to the cellular functioning of the surviving cells. We report here new evidence demonstrating the onset of thermally triggered differentiation in osteosarcoma cancer cells that survive magnetic hyperthermia treatment. This raises the possibility that in addition to causing cell death, magnetic hyperthermia could induce surviving cancer cells to form more mature cell types and thereby inhibit their capacity to self-renew. Such processes could prove to be as important as cell death when considering magnetic hyperthermia for treating cancer.
Original languageEnglish
Pages (from-to)20519-20525
Number of pages7
JournalNanoscale
Volume10
Issue number44
Early online date29 Oct 2018
DOIs
Publication statusPublished - 28 Nov 2018

ASJC Scopus subject areas

  • Materials Science(all)

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