The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling

Wilhelm Engström, Philippa Darbre, Staffan Eriksson, Linda Gulliver, Tove Hultman, Michalis V Karamouzis, James E Klaunig, Rekha Mehta, Kim Moorwood, Thomas Sanderson, Hideko Sone, Pankaj Vadgama, Gerard Wagemaker, Andrew Ward, Neetu Singh, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Anna Maria Colacci, Monica VaccariChiara Mondello, A Ivana Scovassi, Jayadev Raju, Roslida A Hamid, Lorenzo Memeo, Stefano Forte, Rabindra Roy, Jordan Woodrick, Hosni K Salem, Elizabeth P Ryan, Dustin G Brown, William H Bisson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span.

Original languageEnglish
Pages (from-to)S38-S60
JournalCarcinogenesis
Volume36
Issue numberSuppl 1
DOIs
Publication statusPublished - Jun 2015

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Cell Proliferation
Neoplasms
Growth

Keywords

  • Animals
  • Carcinogens, Environmental
  • Cell Proliferation
  • Environmental Exposure
  • Hazardous Substances
  • Humans
  • Neoplasms
  • Signal Transduction
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

Cite this

Engström, W., Darbre, P., Eriksson, S., Gulliver, L., Hultman, T., Karamouzis, M. V., ... Bisson, W. H. (2015). The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis, 36 (Suppl 1), S38-S60. https://doi.org/10.1093/carcin/bgv030

The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. / Engström, Wilhelm; Darbre, Philippa; Eriksson, Staffan; Gulliver, Linda; Hultman, Tove; Karamouzis, Michalis V; Klaunig, James E; Mehta, Rekha; Moorwood, Kim; Sanderson, Thomas; Sone, Hideko; Vadgama, Pankaj; Wagemaker, Gerard; Ward, Andrew; Singh, Neetu; Al-Mulla, Fahd; Al-Temaimi, Rabeah; Amedei, Amedeo; Colacci, Anna Maria; Vaccari, Monica; Mondello, Chiara; Scovassi, A Ivana; Raju, Jayadev; Hamid, Roslida A; Memeo, Lorenzo; Forte, Stefano; Roy, Rabindra; Woodrick, Jordan; Salem, Hosni K; Ryan, Elizabeth P; Brown, Dustin G; Bisson, William H.

In: Carcinogenesis, Vol. 36 , No. Suppl 1, 06.2015, p. S38-S60.

Research output: Contribution to journalArticle

Engström, W, Darbre, P, Eriksson, S, Gulliver, L, Hultman, T, Karamouzis, MV, Klaunig, JE, Mehta, R, Moorwood, K, Sanderson, T, Sone, H, Vadgama, P, Wagemaker, G, Ward, A, Singh, N, Al-Mulla, F, Al-Temaimi, R, Amedei, A, Colacci, AM, Vaccari, M, Mondello, C, Scovassi, AI, Raju, J, Hamid, RA, Memeo, L, Forte, S, Roy, R, Woodrick, J, Salem, HK, Ryan, EP, Brown, DG & Bisson, WH 2015, 'The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling', Carcinogenesis, vol. 36 , no. Suppl 1, pp. S38-S60. https://doi.org/10.1093/carcin/bgv030
Engström, Wilhelm ; Darbre, Philippa ; Eriksson, Staffan ; Gulliver, Linda ; Hultman, Tove ; Karamouzis, Michalis V ; Klaunig, James E ; Mehta, Rekha ; Moorwood, Kim ; Sanderson, Thomas ; Sone, Hideko ; Vadgama, Pankaj ; Wagemaker, Gerard ; Ward, Andrew ; Singh, Neetu ; Al-Mulla, Fahd ; Al-Temaimi, Rabeah ; Amedei, Amedeo ; Colacci, Anna Maria ; Vaccari, Monica ; Mondello, Chiara ; Scovassi, A Ivana ; Raju, Jayadev ; Hamid, Roslida A ; Memeo, Lorenzo ; Forte, Stefano ; Roy, Rabindra ; Woodrick, Jordan ; Salem, Hosni K ; Ryan, Elizabeth P ; Brown, Dustin G ; Bisson, William H. / The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. In: Carcinogenesis. 2015 ; Vol. 36 , No. Suppl 1. pp. S38-S60.
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AU - Karamouzis, Michalis V

AU - Klaunig, James E

AU - Mehta, Rekha

AU - Moorwood, Kim

AU - Sanderson, Thomas

AU - Sone, Hideko

AU - Vadgama, Pankaj

AU - Wagemaker, Gerard

AU - Ward, Andrew

AU - Singh, Neetu

AU - Al-Mulla, Fahd

AU - Al-Temaimi, Rabeah

AU - Amedei, Amedeo

AU - Colacci, Anna Maria

AU - Vaccari, Monica

AU - Mondello, Chiara

AU - Scovassi, A Ivana

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AU - Hamid, Roslida A

AU - Memeo, Lorenzo

AU - Forte, Stefano

AU - Roy, Rabindra

AU - Woodrick, Jordan

AU - Salem, Hosni K

AU - Ryan, Elizabeth P

AU - Brown, Dustin G

AU - Bisson, William H

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KW - Hazardous Substances

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