The PI3K inhibitor arsenal: choose your weapon!

T Crabbe, Melanie Welham, Stephen Ward

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Owing to its widespread activation in inflammation and cancer, a growing appreciation of the therapeutic potential of inhibitors of the phosphoinositide 3-kinase (PI3K) pathway has stimulated intense interest in compounds with suitable pharmacological profiles. These are primarily directed toward PI3K itself. However, as class I PI3Ks are also essential for a range of normal physiological processes, broad spectrum PI3K inhibition could be poorly tolerated. In recent years, patents describing a new generation of PI3K inhibitors have started to appear, with a particular focus on the development of compounds with enhanced isoform selectivity for use as anti-cancer and anti-inflammatory therapies. However, challenges remain for the efforts to pharmacologically target this enzyme family in a successful manner.
Original languageEnglish
Pages (from-to)450-456
Number of pages7
JournalTrends in Biochemical Sciences
Volume32
Issue number10
DOIs
Publication statusPublished - 2007

Fingerprint Dive into the research topics of 'The PI3K inhibitor arsenal: choose your weapon!'. Together they form a unique fingerprint.

  • Cite this