The perils of rational design – unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S)

Maksims Jevglevskis; Guat L. Lee; Michael D. Threadgill; Timothy J. Woodman; Matthew D. Lloyd

doi:10.1039/C4CC06127F

The perils of rational design – unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S)

Maksims Jevglevskis, Guat L. Lee, Michael D. Threadgill, Timothy J. Woodman, Matthew D. Lloyd

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (SciVal)

395 Downloads (Pure)

Original language	English
Pages (from-to)	14164-14166
Journal	Chemical Communications
Volume	50
Issue number	91
Early online date	18 Sept 2014
DOIs	https://doi.org/10.1039/C4CC06127F
Publication status	Published - 28 Nov 2014

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10.1039/C4CC06127F

Accepted versionAccepted author manuscript, 578 KB
Supplemental information

2 Finished

AMACR Targeted Drugs for Treating Advance Prostate Cancer
Lloyd, M. (PI), James, T. (CoI), Jevglevskis, M. (CoI), Nathubhai, A. (CoI), Threadgill, M. (CoI) & Woodman, T. (CoI)
Prostate Cancer UK
1/02/15 → 30/07/18
Project: UK charity
Targeting AMACR to Treat Castrate Resistant Prostate Cancer
Lloyd, M. (PI) & Woodman, T. (CoI)
Prostate Cancer UK
5/10/11 → 31/01/15
Project: UK charity

Matthew Lloyd
- M.D.Lloydbath.acuk
- Department of Life Sciences - Senior Lecturer
Person: Research & Teaching
Tim Woodman
- Material and Chemical Characterisation (MC2)
Person: Teaching & Other

Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)
Material and Chemical Characterisation (MC2)
Facility/equipment: Equipment
MC2- Nuclear Magnetic Resonance (NMR)
Material and Chemical Characterisation (MC2)
Facility/equipment: Technology type

Cite this

The perils of rational design – unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S). / Jevglevskis, Maksims; Lee, Guat L.; Threadgill, Michael D. et al.
In: Chemical Communications, Vol. 50, No. 91, 28.11.2014, p. 14164-14166.

Research output: Contribution to journal › Article › peer-review

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The perils of rational design – unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S)

Access to Document

Projects

AMACR Targeted Drugs for Treating Advance Prostate Cancer

Targeting AMACR to Treat Castrate Resistant Prostate Cancer

Profiles

Matthew Lloyd

Tim Woodman

Equipment

Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)

MC2- Nuclear Magnetic Resonance (NMR)

Cite this