TY - JOUR
T1 - The "other" inositols and their phosphates
T2 - synthesis, biology, and medicine (with recent advances in myo-inositol chemistry)
AU - Thomas, Mark P.
AU - Mills, Stephen J.
AU - Potter, Barry V. L.
PY - 2016/1/26
Y1 - 2016/1/26
N2 - Cell signaling via inositol phosphates, in particular via the second messenger myo-inositol 1,4,5-trisphosphate, and phosphoinositides comprises a huge field of biology. Of the nine 1,2,3,4,5,6-cyclohexanehexol isomers, myo-inositol is pre-eminent, with "other" inositols (cis-, epi-, allo-, muco-, neo-, L-chiro-, D-chiro-, and scyllo-) and derivatives rarer or thought not to exist in nature. However, neo- and D-chiro-inositol hexakisphosphates were recently revealed in both terrestrial and aquatic ecosystems, thus highlighting the paucity of knowledge of the origins and potential biological functions of such stereoisomers, a prevalent group of environmental organic phosphates, and their parent inositols. Some "other" inositols are medically relevant, for example, scyllo-inositol (neurodegenerative diseases) and D-chiro-inositol (diabetes). It is timely to consider exploration of the roles and applications of the "other" isomers and their derivatives, likely by exploiting techniques now well developed for the myo series.
AB - Cell signaling via inositol phosphates, in particular via the second messenger myo-inositol 1,4,5-trisphosphate, and phosphoinositides comprises a huge field of biology. Of the nine 1,2,3,4,5,6-cyclohexanehexol isomers, myo-inositol is pre-eminent, with "other" inositols (cis-, epi-, allo-, muco-, neo-, L-chiro-, D-chiro-, and scyllo-) and derivatives rarer or thought not to exist in nature. However, neo- and D-chiro-inositol hexakisphosphates were recently revealed in both terrestrial and aquatic ecosystems, thus highlighting the paucity of knowledge of the origins and potential biological functions of such stereoisomers, a prevalent group of environmental organic phosphates, and their parent inositols. Some "other" inositols are medically relevant, for example, scyllo-inositol (neurodegenerative diseases) and D-chiro-inositol (diabetes). It is timely to consider exploration of the roles and applications of the "other" isomers and their derivatives, likely by exploiting techniques now well developed for the myo series.
KW - Cyclitols
KW - Inositol
KW - Isomers
KW - Phosphates
KW - Synthetic methods
UR - http://www.scopus.com/inward/record.url?scp=84952705442&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1002/anie.201502227
U2 - 10.1002/anie.201502227
DO - 10.1002/anie.201502227
M3 - Article
SN - 1433-7851
VL - 55
SP - 1614
EP - 1650
JO - Angewandte Chemie-International Edition
JF - Angewandte Chemie-International Edition
IS - 5
ER -