The Na+/K+-ATPase is the Achilles Heel of multi-drug-resistant cancer cells

Tatjana Mijatovic; Ute Jungwirth; Petra Heffeter; Mir Ali Reza Hoda; Rita Dornetshuber; Robert Kiss; Walter Berger

doi:10.1016/j.canlet.2009.02.048

The Na⁺/K⁺-ATPase is the Achilles Heel of multi-drug-resistant cancer cells

Tatjana Mijatovic, Ute Jungwirth, Petra Heffeter, Mir Ali Reza Hoda, Rita Dornetshuber, Robert Kiss, Walter Berger

Research output: Contribution to journal › Article › peer-review

39 Citations (SciVal)

Abstract

We recently reported that over-expressed Na⁺/K⁺-ATPase α subunits are new important anti-cancer targets. Cardiotonic steroids are the natural ligands of Na⁺/K⁺-ATPase and thus potentially potent anti-cancer agents with a novel mechanism of action. We report here that the hemi-synthetic cardenolide 19-hydroxy-2″oxovoruscharin is impressively active in cancer cells expressing diverse forms of multi-drug resistance (MDR) either conferred by the over-expression of selected drug-transporter proteins or induced by a range of chemotherapeutic agents. Together with the inability of tumor cells to acquire resistance to 19-hydroxy-2″oxovoruscharin, our data suggest that this novel compound could be especially applicable to notoriously drug-resistant cancers.

Original language	English
Pages (from-to)	30-34
Number of pages	5
Journal	Cancer Letters
Volume	282
Issue number	1
Early online date	31 Mar 2009
DOIs	https://doi.org/10.1016/j.canlet.2009.02.048
Publication status	Published - 8 Sept 2009

Bibliographical note

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

19-hydroxy-2″oxovoruscharin
Cardenolide
Multi-drug resistance (MDR)
Na/K-ATPase targeting

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/j.canlet.2009.02.048

Cite this

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title = "The Na+/K+-ATPase is the Achilles Heel of multi-drug-resistant cancer cells",

abstract = "We recently reported that over-expressed Na+/K+-ATPase α subunits are new important anti-cancer targets. Cardiotonic steroids are the natural ligands of Na+/K+-ATPase and thus potentially potent anti-cancer agents with a novel mechanism of action. We report here that the hemi-synthetic cardenolide 19-hydroxy-2″oxovoruscharin is impressively active in cancer cells expressing diverse forms of multi-drug resistance (MDR) either conferred by the over-expression of selected drug-transporter proteins or induced by a range of chemotherapeutic agents. Together with the inability of tumor cells to acquire resistance to 19-hydroxy-2″oxovoruscharin, our data suggest that this novel compound could be especially applicable to notoriously drug-resistant cancers.",

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AU - Mijatovic, Tatjana

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AU - Dornetshuber, Rita

AU - Kiss, Robert

AU - Berger, Walter

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