The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formation

V Sherwood, Asha Recino, Alex Jeffries, Andrew Ward, Andrew D Chalmers

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Abstract

The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the classical RASSF proteins (RASSF1–6) and the four recently added N-terminal RASSF proteins (RASSF7–10). The N-terminal RASSF proteins have a number of differences from the classical RASSF members and represent a newly defined set of potential Ras effectors. They have been linked to key biological processes, including cell death, proliferation, microtubule stability, promoter methylation, vesicle trafficking and response to hypoxia. Two members of the N-terminal RASSF family have also been highlighted as potential tumour suppressors. The present review will summarize what is known about the N-terminal RASSF proteins, addressing their function and possible links to cancer formation. It will also compare the N-terminal RASSF proteins with the classical RASSF proteins and ask whether the N-terminal RASSF proteins should be considered as genuine members or imposters in the RASSF family.
LanguageEnglish
Pages303-311
Number of pages9
JournalBiochemical Journal
Volume425
Issue number2
DOIs
StatusPublished - 2010

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Association reactions
Neoplasms
Proteins
Tumors
Protein Domains
Methylation
Cell death
Biological Phenomena
Microtubules
Cell Death
Cell Proliferation

Cite this

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title = "The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formation",
abstract = "The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the classical RASSF proteins (RASSF1–6) and the four recently added N-terminal RASSF proteins (RASSF7–10). The N-terminal RASSF proteins have a number of differences from the classical RASSF members and represent a newly defined set of potential Ras effectors. They have been linked to key biological processes, including cell death, proliferation, microtubule stability, promoter methylation, vesicle trafficking and response to hypoxia. Two members of the N-terminal RASSF family have also been highlighted as potential tumour suppressors. The present review will summarize what is known about the N-terminal RASSF proteins, addressing their function and possible links to cancer formation. It will also compare the N-terminal RASSF proteins with the classical RASSF proteins and ask whether the N-terminal RASSF proteins should be considered as genuine members or imposters in the RASSF family.",
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TY - JOUR

T1 - The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formation

AU - Sherwood,V

AU - Recino,Asha

AU - Jeffries,Alex

AU - Ward,Andrew

AU - Chalmers,Andrew D

PY - 2010

Y1 - 2010

N2 - The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the classical RASSF proteins (RASSF1–6) and the four recently added N-terminal RASSF proteins (RASSF7–10). The N-terminal RASSF proteins have a number of differences from the classical RASSF members and represent a newly defined set of potential Ras effectors. They have been linked to key biological processes, including cell death, proliferation, microtubule stability, promoter methylation, vesicle trafficking and response to hypoxia. Two members of the N-terminal RASSF family have also been highlighted as potential tumour suppressors. The present review will summarize what is known about the N-terminal RASSF proteins, addressing their function and possible links to cancer formation. It will also compare the N-terminal RASSF proteins with the classical RASSF proteins and ask whether the N-terminal RASSF proteins should be considered as genuine members or imposters in the RASSF family.

AB - The RASSF (Ras-association domain family) has recently gained several new members and now contains ten proteins (RASSF1–10), several of which are potential tumour suppressors. The family can be split into two groups, the classical RASSF proteins (RASSF1–6) and the four recently added N-terminal RASSF proteins (RASSF7–10). The N-terminal RASSF proteins have a number of differences from the classical RASSF members and represent a newly defined set of potential Ras effectors. They have been linked to key biological processes, including cell death, proliferation, microtubule stability, promoter methylation, vesicle trafficking and response to hypoxia. Two members of the N-terminal RASSF family have also been highlighted as potential tumour suppressors. The present review will summarize what is known about the N-terminal RASSF proteins, addressing their function and possible links to cancer formation. It will also compare the N-terminal RASSF proteins with the classical RASSF proteins and ask whether the N-terminal RASSF proteins should be considered as genuine members or imposters in the RASSF family.

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