The molecular basis of transdifferentiation

W C Li, W Y Yu, Jonathan M Quinlan, Z D Burke, D Tosh

Research output: Contribution to journalArticlepeer-review

58 Citations (SciVal)


There is now excellent experimental evidence demonstrating the remarkable ability of some differentiated cells to convert to a completely different phenotype. The conversion of one cellular phenotype to another is referred to as 'transdifferentiation' and belongs to a wider class of cell-type switches termed 'metaplasias'. Defining the molecular steps in transdifferentiation will help us to understand the developmental biology of the cells that interconvert, as well as help identify key regulatory transcription factors that may be important for the reprogramming of stem cells. Ultimately, being able to produce cells at will offers a compelling new approach to therapeutic transplantation and therefore the treatment and cure of diseases such as diabetes.
Original languageEnglish
Pages (from-to)569-582
Number of pages14
JournalJournal of Cellular and Molecular Medicine
Issue number3
Publication statusPublished - Jul 2005


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