Abstract
HIV pre-exposure prophylaxis (PrEP) is said to have transformed pleasure and sexual practices in myriad ways. This article draws on interviews with PrEP users in Australia who had paused, stopped, or switched PrEP use in order to explore the varied affects and experiences of PrEP in relation to different dosing strategies. Drawing on the concept of ‘desiring-assemblages’, we considered ‘what can a body with PrEP do?’. Our analysis affirms PrEP as transformative, enabling freedom through reduced or removed fear of HIV transmission. However, participant accounts also suggested that PrEP has been normalised as an ordinary part of sexual cultures, with some indicating that PrEP use was felt as obligatory or ambivalent. Daily and nondaily dosing also potentiated different flows of desire and connections, remaking what PrEP is and can be in participants’ lives in ways that trouble the idea that PrEP consistently facilitates pleasure. PrEP dosing was framed by discussion of changes to one’s sense of self and future priorities, and through ideas about freedom, pleasure, shame, safety, obligation, fitting in, waste, and potential. While PrEP is increasingly promoted through messaging linked to ‘pleasure’, instead of earlier discourses of ‘risk’, a pleasure-centric focus may delimit understandings of how PrEP can produce multiple sexual lives and practices, including the mundane aspects of sex and pleasure. To appeal to a range of potential PrEP users, health promotion should emphasise the different possibilities for PrEP – it’s potential for pleasure, its critical role in preventing HIV, and its normative mundanity.
| Original language | English |
|---|---|
| Journal | Sexualities |
| Early online date | 2 Jan 2026 |
| DOIs | |
| Publication status | E-pub ahead of print - 2 Jan 2026 |
Data Availability Statement
Research data are not sharedAcknowledgements
We thank the participants for generously sharing their stories with us. We also thank our community partners ACON and Thorne Harbour Health, along with Mo Hammoud, James MacGibbon, and Daniel Storer for assistance with recruitment. Conversations within the Evidence-Making Interventions in Health team were also important for conceptualising aspects of this article, and we acknowledge Sophie Adams and Mia Harrison for their critical dialogue, and Marsha Rosengarten and Carla Treloar as co-investigators of the wider project from which this study was drawn.Funding
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This project was supported by an Australian Research Council Discovery Project grant (DP210101604) and by an Australian Research Council DECRA Fellowship (DE230100642). We are also grateful for support from the UNSW SHARP (Professor Tim Rhodes) and Scientia (Professor Kari Lancaster) schemes.
Keywords
- assemblage
- Australia
- evidence-making intervention
- gay and bisexual men
- qualitative
ASJC Scopus subject areas
- Gender Studies
- Anthropology