The Lab-on-PCB approach: Tackling the μTAS commercial upscaling bottleneck

Despina Moschou, Angeliki Tserepi

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Commercialization of Lab-on-Chip devices is currently the “holy grail” within the μTAS research community. While a wide variety of highly sophisticated chips which could potentially revolutionize healthcare, biology, chemistry and all related disciplines is increasingly being demonstrated, very few chips are or can be adopted by the market and reach the end-users. The major inhibition factor lies with the lack of an established commercial manufacturing technology. The Lab-on-Printed Circuit Board (Lab-on-PCB) approach, while suggested many years ago, only recently has re-emerged as a very strong candidate, owing to its inherent upscaling potential: the PCB industry is well-established all around the world, with standardized fabrication facilities and processes, however commercially exploited currently only for electronics. Owing to these characteristics, complex μTAS integrating microfluidics, sensors, and electronics on the same PCB platform can easily be upscaled, provided more processes and prototypes adapted to the PCB industry are proposed. In this article, we will be reviewing for the first time the PCB-based prototypes presented in literature to date, highlighting the upscaling potential of this technology. The authors believe that further evolution of this technology has the potential to become a much sought-after standardized industrial fabrication technology for low-cost μTAS, which could in turn trigger the projected exponential market growth of μTAS, in a fashion analogous to the revolution of Si microchips via the CMOS industry establishment.
Original languageEnglish
Pages (from-to)1388-1405
JournalLab on a Chip
Volume17
Issue number8
Early online date6 Mar 2017
DOIs
Publication statusPublished - 21 Apr 2017

Fingerprint

Polychlorinated Biphenyls
Polychlorinated biphenyls
Printed circuit boards
Technology
Industry
Electronic equipment
Fabrication
Microfluidics
Delivery of Health Care
Costs and Cost Analysis
Equipment and Supplies
Sensors
Growth
Research
Costs

Cite this

The Lab-on-PCB approach: Tackling the μTAS commercial upscaling bottleneck. / Moschou, Despina; Tserepi, Angeliki.

In: Lab on a Chip, Vol. 17, No. 8, 21.04.2017, p. 1388-1405.

Research output: Contribution to journalReview article

@article{887ea1ff20f9453d8c4cfea5e9a601a0,
title = "The Lab-on-PCB approach: Tackling the μTAS commercial upscaling bottleneck",
abstract = "Commercialization of Lab-on-Chip devices is currently the “holy grail” within the μTAS research community. While a wide variety of highly sophisticated chips which could potentially revolutionize healthcare, biology, chemistry and all related disciplines is increasingly being demonstrated, very few chips are or can be adopted by the market and reach the end-users. The major inhibition factor lies with the lack of an established commercial manufacturing technology. The Lab-on-Printed Circuit Board (Lab-on-PCB) approach, while suggested many years ago, only recently has re-emerged as a very strong candidate, owing to its inherent upscaling potential: the PCB industry is well-established all around the world, with standardized fabrication facilities and processes, however commercially exploited currently only for electronics. Owing to these characteristics, complex μTAS integrating microfluidics, sensors, and electronics on the same PCB platform can easily be upscaled, provided more processes and prototypes adapted to the PCB industry are proposed. In this article, we will be reviewing for the first time the PCB-based prototypes presented in literature to date, highlighting the upscaling potential of this technology. The authors believe that further evolution of this technology has the potential to become a much sought-after standardized industrial fabrication technology for low-cost μTAS, which could in turn trigger the projected exponential market growth of μTAS, in a fashion analogous to the revolution of Si microchips via the CMOS industry establishment.",
author = "Despina Moschou and Angeliki Tserepi",
year = "2017",
month = "4",
day = "21",
doi = "10.1039/C7LC00121E",
language = "English",
volume = "17",
pages = "1388--1405",
journal = "Lab on a Chip",
issn = "1473-0197",
publisher = "Royal Society of Chemistry",
number = "8",

}

TY - JOUR

T1 - The Lab-on-PCB approach: Tackling the μTAS commercial upscaling bottleneck

AU - Moschou, Despina

AU - Tserepi, Angeliki

PY - 2017/4/21

Y1 - 2017/4/21

N2 - Commercialization of Lab-on-Chip devices is currently the “holy grail” within the μTAS research community. While a wide variety of highly sophisticated chips which could potentially revolutionize healthcare, biology, chemistry and all related disciplines is increasingly being demonstrated, very few chips are or can be adopted by the market and reach the end-users. The major inhibition factor lies with the lack of an established commercial manufacturing technology. The Lab-on-Printed Circuit Board (Lab-on-PCB) approach, while suggested many years ago, only recently has re-emerged as a very strong candidate, owing to its inherent upscaling potential: the PCB industry is well-established all around the world, with standardized fabrication facilities and processes, however commercially exploited currently only for electronics. Owing to these characteristics, complex μTAS integrating microfluidics, sensors, and electronics on the same PCB platform can easily be upscaled, provided more processes and prototypes adapted to the PCB industry are proposed. In this article, we will be reviewing for the first time the PCB-based prototypes presented in literature to date, highlighting the upscaling potential of this technology. The authors believe that further evolution of this technology has the potential to become a much sought-after standardized industrial fabrication technology for low-cost μTAS, which could in turn trigger the projected exponential market growth of μTAS, in a fashion analogous to the revolution of Si microchips via the CMOS industry establishment.

AB - Commercialization of Lab-on-Chip devices is currently the “holy grail” within the μTAS research community. While a wide variety of highly sophisticated chips which could potentially revolutionize healthcare, biology, chemistry and all related disciplines is increasingly being demonstrated, very few chips are or can be adopted by the market and reach the end-users. The major inhibition factor lies with the lack of an established commercial manufacturing technology. The Lab-on-Printed Circuit Board (Lab-on-PCB) approach, while suggested many years ago, only recently has re-emerged as a very strong candidate, owing to its inherent upscaling potential: the PCB industry is well-established all around the world, with standardized fabrication facilities and processes, however commercially exploited currently only for electronics. Owing to these characteristics, complex μTAS integrating microfluidics, sensors, and electronics on the same PCB platform can easily be upscaled, provided more processes and prototypes adapted to the PCB industry are proposed. In this article, we will be reviewing for the first time the PCB-based prototypes presented in literature to date, highlighting the upscaling potential of this technology. The authors believe that further evolution of this technology has the potential to become a much sought-after standardized industrial fabrication technology for low-cost μTAS, which could in turn trigger the projected exponential market growth of μTAS, in a fashion analogous to the revolution of Si microchips via the CMOS industry establishment.

UR - https://doi.org/10.1039/C7LC00121E

U2 - 10.1039/C7LC00121E

DO - 10.1039/C7LC00121E

M3 - Review article

VL - 17

SP - 1388

EP - 1405

JO - Lab on a Chip

JF - Lab on a Chip

SN - 1473-0197

IS - 8

ER -