The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Valeska P. Ting; Marc Schmidtmann; Paul F. Henry; Sandie E. Dann; Jenna L. Crisp; Chick  C. Wilson; Mark T. Weller

doi:10.1039/c0md00093k

The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Valeska P. Ting, Marc Schmidtmann, Paul F. Henry, Sandie E. Dann, Jenna L. Crisp, Chick C. Wilson, Mark T. Weller

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Abstract

The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

Original language	English
Pages (from-to)	345-348
Journal	MedChemComm
Volume	1
Issue number	5
Early online date	10 Oct 2010
DOIs	https://doi.org/10.1039/c0md00093k
Publication status	Published - 2010

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title = "The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction",

abstract = "The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.",

author = "Ting, {Valeska P.} and Marc Schmidtmann and Henry, {Paul F.} and Dann, {Sandie E.} and Crisp, {Jenna L.} and Wilson, {Chick C.} and Weller, {Mark T.}",

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AU - Ting, Valeska P.

AU - Schmidtmann, Marc

AU - Henry, Paul F.

AU - Dann, Sandie E.

AU - Crisp, Jenna L.

AU - Wilson, Chick C.

AU - Weller, Mark T.

PY - 2010

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N2 - The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

AB - The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.

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The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Abstract

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