The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by in situ neutron powder diffraction

Valeska P. Ting, Marc Schmidtmann, Paul F. Henry, Sandie E. Dann, Jenna L. Crisp, Chick C. Wilson, Mark T. Weller

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Abstract

The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.
Original languageEnglish
Pages (from-to)345-348
JournalMedChemComm
Volume1
Issue number5
Early online date10 Oct 2010
DOIs
Publication statusPublished - 2010

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