The insect toxin complex of Yersinia

N Waterfield, M Hares, S Hinchliffe, B Wren, R Ffrench-Constant

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Citations (Scopus)

Abstract

Many members of the Yersinia genus encode homologues of insect toxins first observed in bacteria that are insect pathogens such as Photorhabdus, Xenorhabdus and Serratia entomophila. These bacteria secrete high molecular weight insecticidal toxins comprised of multiple protein subunits, termed the Toxin Complexes or Tc's. In Photorhabdus three distinct Tc subunits are required for full oral toxicity in insects, that include the [A], [B] and [C] types, although the exact stochiometry remains unclear. The genomes of Photorhabdus strains encode multiple tc loci, although only two have been shown to exhibit oral and injectable activity against the Hawk Moth, Manduca sexta. The exact role of the remaining homologues is unclear. The availability of bacterial genome sequences has revealed the presence of tc gene homologues in many different species. In this chapter we review the tc gene homologues in Yersinia genus. We discuss what is known about the activity of the Yersinia Tc protein homologues and attempt to relate this to the evolution of the genus and of the tca gene family.
Original languageEnglish
Title of host publicationGenus Yersinia: From Genomics to Function
PublisherSpringer
Pages247-257
Number of pages11
Volume603
ISBN (Print)0065-2598
DOIs
Publication statusPublished - 2007

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer

Fingerprint

Photorhabdus
Yersinia
toxins
insects
Serratia entomophila
Xenorhabdus
Sphingidae
entomopathogens
genome
genes
bacteria
Manduca sexta
protein subunits
mouth
molecular weight
loci
proteins

Cite this

Waterfield, N., Hares, M., Hinchliffe, S., Wren, B., & Ffrench-Constant, R. (2007). The insect toxin complex of Yersinia. In Genus Yersinia: From Genomics to Function (Vol. 603, pp. 247-257). (Advances in Experimental Medicine and Biology). Springer. https://doi.org/10.1007/978-0-387-72124-8

The insect toxin complex of Yersinia. / Waterfield, N; Hares, M; Hinchliffe, S; Wren, B; Ffrench-Constant, R.

Genus Yersinia: From Genomics to Function. Vol. 603 Springer, 2007. p. 247-257 (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Waterfield, N, Hares, M, Hinchliffe, S, Wren, B & Ffrench-Constant, R 2007, The insect toxin complex of Yersinia. in Genus Yersinia: From Genomics to Function. vol. 603, Advances in Experimental Medicine and Biology, Springer, pp. 247-257. https://doi.org/10.1007/978-0-387-72124-8
Waterfield N, Hares M, Hinchliffe S, Wren B, Ffrench-Constant R. The insect toxin complex of Yersinia. In Genus Yersinia: From Genomics to Function. Vol. 603. Springer. 2007. p. 247-257. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-0-387-72124-8
Waterfield, N ; Hares, M ; Hinchliffe, S ; Wren, B ; Ffrench-Constant, R. / The insect toxin complex of Yersinia. Genus Yersinia: From Genomics to Function. Vol. 603 Springer, 2007. pp. 247-257 (Advances in Experimental Medicine and Biology).
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