TY - JOUR
T1 - The initial release of cisplatin from poly(lactide-co-glycolide) microspheres
AU - Lee, Y S
AU - Lowe, J P
AU - Gilby, E
AU - Perera, Semali P
AU - Rigby, S P
PY - 2010/1/4
Y1 - 2010/1/4
N2 - PLGA microspheres loaded with cisplatin were produced using a single emulsion method. A semi-empirical model, with bi-exponential terms, was found to give a better fit to the drug release profiles compared to a mono-exponential model. This model suggests that there are two separate fractions of drug present in the depot. A fraction of the drug is located near/at the surface of the depot, and is readily released during immersion in buffer. A second fraction of drug is entrapped deeper within the depot and is subsequently released. It was also found that the initial release of cisplatin from PLGA microsphere is highly diffusion-controlled and the classical Higuchi model provides a good fit. From studies of water diffusion using PFG-NMR, results suggested that 50:50 PLGA microsphere was most susceptible to swelling and this might have promoted the faster initial drug release. Results from NMR cryoporometry also indicated that the developed PLGA microspheres could have "ink-bottle" pores. (C) 2009 Elsevier B.V. All rights reserved.
AB - PLGA microspheres loaded with cisplatin were produced using a single emulsion method. A semi-empirical model, with bi-exponential terms, was found to give a better fit to the drug release profiles compared to a mono-exponential model. This model suggests that there are two separate fractions of drug present in the depot. A fraction of the drug is located near/at the surface of the depot, and is readily released during immersion in buffer. A second fraction of drug is entrapped deeper within the depot and is subsequently released. It was also found that the initial release of cisplatin from PLGA microsphere is highly diffusion-controlled and the classical Higuchi model provides a good fit. From studies of water diffusion using PFG-NMR, results suggested that 50:50 PLGA microsphere was most susceptible to swelling and this might have promoted the faster initial drug release. Results from NMR cryoporometry also indicated that the developed PLGA microspheres could have "ink-bottle" pores. (C) 2009 Elsevier B.V. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=70449522977&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1016/j.ijpharm.2009.09.021
U2 - 10.1016/j.ijpharm.2009.09.021
DO - 10.1016/j.ijpharm.2009.09.021
M3 - Article
SN - 0378-5173
VL - 383
SP - 244
EP - 254
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -