The initial release of cisplatin from poly(lactide-co-glycolide) microspheres

Y S Lee, J P Lowe, E Gilby, Semali P Perera, S P Rigby

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

PLGA microspheres loaded with cisplatin were produced using a single emulsion method. A semi-empirical model, with bi-exponential terms, was found to give a better fit to the drug release profiles compared to a mono-exponential model. This model suggests that there are two separate fractions of drug present in the depot. A fraction of the drug is located near/at the surface of the depot, and is readily released during immersion in buffer. A second fraction of drug is entrapped deeper within the depot and is subsequently released. It was also found that the initial release of cisplatin from PLGA microsphere is highly diffusion-controlled and the classical Higuchi model provides a good fit. From studies of water diffusion using PFG-NMR, results suggested that 50:50 PLGA microsphere was most susceptible to swelling and this might have promoted the faster initial drug release. Results from NMR cryoporometry also indicated that the developed PLGA microspheres could have "ink-bottle" pores. (C) 2009 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)244-254
Number of pages11
JournalInternational Journal of Pharmaceutics
Volume383
Issue number1-2
Early online date16 Sep 2009
DOIs
Publication statusPublished - 4 Jan 2010

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