The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans

Neusa L. Figueiredo, Sara Raquel M.M. de Aguiar, Pedro Luis Falé, Lia Ascensão, Maria Luisa M. Serralheiro, Ana Rosa L. Lino

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Aqueous extracts of Plectranthus barbatus and Plectranthus ecklonii are traditionally used as anti-inflammatory and anti-fungal agents. The effect of these extracts and of its main component, rosmarinic acid, on the viability of the cariogenic bacteria, Streptococcus sobrinus and Streptococcus mutans, was determined by MIC and MBC. The influence of these extracts on the biofilm formation as well as on the inhibition of glucosyltransferase enzyme, produced by these species, was also analysed. Aqueous extracts of P. barbatus and P. ecklonii were stronger inhibitors than rosmarinic acid. MIC values of 3.8 and 4.7 mg/ml for S. sobrinus and 2.9 and 5.0 for S. mutans were obtained, while rosmarinic acid presented MIC values of 8.4 and 7.3 mg/ml. P. barbartus, P. ecklonii and rosmarinic acid presented MBC values of 9.5, 9.0 and 12.0 mg/ml for S. sobrinus, and 9.5, 10.0 and 12.5 mg/ml for S. mutans. The inhibition of biofilm formation by P. barbatus, P. ecklonii and rosmarinic acid presented IC50 values of, respectively, 0.6, 1.0 and 3.1 mg/ml for S. sobrinus and 1.4 and 2.7 and 1.3 mg/ml for S. mutans. The glucosyltransferase inhibition activity by theses extracts and rosmarinic acid was calculated and IC50 values presented were, respectively, 1.1, ca 1.2 and 2.1 mg/ml for S. sobrinus and 3.1, 1.6 and 3.9 mg/ml for S. mutans were obtained. These extracts may be useful in the prevention of dental carie.

Original languageEnglish
Pages (from-to)664-668
Number of pages5
JournalFood Chemistry
Volume119
Issue number2
DOIs
Publication statusPublished - 15 Mar 2010

Keywords

  • Biofilm formation
  • Glucosyltransferase activity
  • Plectranthus barbatus
  • Plectranthus ecklonii
  • Streptococcus mutans
  • Streptococcus sobrinus

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science
  • Medicine(all)

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