The Influence of Urea on Percutaneous Absorption

Janet Beastall; Richard H. Guy; Jonathan Hadgraft; Ian Wilding

doi:10.1023/A:1016315519599

The Influence of Urea on Percutaneous Absorption

Janet Beastall, Richard H. Guy, Jonathan Hadgraft, Ian Wilding

Research output: Contribution to journal › Article › peer-review

Abstract

The release characteristics of aqueous and oily creams (BP) containing urea up to concentrations of 10% have been studied. The results show that the urea has little influence on the ability of the formulation to release its active ingredient, in this case, hexyl nicotinate. The preparations were then assessed in an in vivo experiment by measuring the time of onset of erythema induced by the hexyl nicotinate. The urea influenced the time of onset of erythema, and a mechanism for its action is proposed.

Original language	English
Pages (from-to)	294-297
Number of pages	4
Journal	Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Volume	3
Issue number	5
DOIs	https://doi.org/10.1023/A:1016315519599
Publication status	Published - 31 Oct 1986

Keywords

hexyl nicotinate
penetration enhancers
percutaneous absorption
urea

ASJC Scopus subject areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

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The Influence of Urea on Percutaneous Absorption

Abstract

Keywords

ASJC Scopus subject areas

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