The release characteristics of aqueous and oily creams (BP) containing urea up to concentrations of 10% have been studied. The results show that the urea has little influence on the ability of the formulation to release its active ingredient, in this case, hexyl nicotinate. The preparations were then assessed in an in vivo experiment by measuring the time of onset of erythema induced by the hexyl nicotinate. The urea influenced the time of onset of erythema, and a mechanism for its action is proposed.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Issue number5
Publication statusPublished - 31 Oct 1986


  • hexyl nicotinate
  • penetration enhancers
  • percutaneous absorption
  • urea

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)


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