The influence of crystals, particles and powders on the performance of dry powder inhalers

Jagdeep Shur, Robert Price

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dry powder inhalers (DPIs) are an attractive means of delivering drugs to the lung. The fluidization, entrainment and de-aggregation of a DPI formulation is a complex relationship between the patient's inspiratory effort, the air flow field generated within a device and the cohesive properties of the powder bed. The inter-relationship between factors including particle size, particle shape, distribution of interparticulate and mechanical forces govern the performance and efficacy of DPI drug delivery systems. However, quantitative measurements of these properties and their under-lying relationships remain difficult to discern. This presentation will focus on some key developments in understanding the relationships between the governing properties of DPIs and how these properties can be harnessed to develop designer formulation systems for DPIs.
Original languageEnglish
Title of host publication2011 AIChE Annual Meeting, Conference Proceedings
PublisherCurran Associates, Inc.
ISBN (Print)9780816910700
Publication statusPublished - 2011
Event2011 AIChE Annual Meeting - Minneapolis, USA United States
Duration: 16 Oct 201121 Oct 2011

Conference

Conference2011 AIChE Annual Meeting
Abbreviated title11AIChE
CountryUSA United States
CityMinneapolis
Period16/10/1121/10/11

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    Shur, J., & Price, R. (2011). The influence of crystals, particles and powders on the performance of dry powder inhalers. In 2011 AIChE Annual Meeting, Conference Proceedings Curran Associates, Inc..