The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women

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Abstract

Objective: To establish whether vigorous-intensity exercise offers additional adipose-related health benefits and metabolic improvements compared to energy-matched moderate-intensity exercise.Methods: Thirty-eight sedentary overweight men (n=24) and postmenopausal women (n=14) aged 52 ± 5 years (mean ± SD) were prescribed a 3-week energy deficit (29302 kJ·week-1) achieved by increased isocaloric moderate or vigorous-intensity exercise (+8372 kJ·week-1) and simultaneous restricted energy intake (-20930 kJ·week-1). Participants were randomly assigned to either an energy-matched vigorous (VIG; n=18) or moderate (MOD; n=20) intensity exercise group (five times per week at 70% or 50% maximal oxygen uptake, respectively). At baseline and follow-up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted.Results: Body mass was reduced similarly in both groups (Δ 2.4 ± 1.1 kg and Δ 2.4 ± 1.4 kg, respectively, P<0.05). Insulinaemic responses to a standard glucose load decreased similarly at follow-up relative to baseline in VIG (Δ 8.6 ± 15.4 nmol.120min.l-1) and MOD (Δ 5.4 ± 8.5 nmol.120min.l-1; P<0.05). Expression of SREBP-1c and FAS in adipose tissue was significantly down-regulated whereas expression of PDK4 and HSL was significantly up-regulated in both groups (P<0.05).Conclusions: When energy expenditure and energy deficit are matched, vigorous or moderate-intensity exercise combined with energy restriction provide broadly similar (positive) changes in metabolic control and adipose tissue gene expression.
Original languageEnglish
Article numbere13026
JournalPhysiological Reports
Volume4
Issue number24
DOIs
Publication statusPublished - 30 Dec 2016

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Energy Metabolism
Adipose Tissue
Exercise
Abdominal Subcutaneous Fat
Sterol Regulatory Element Binding Protein 1
Insurance Benefits
Glucose Tolerance Test
Energy Intake
Oxygen
Biopsy
Gene Expression
Glucose

Keywords

  • Exercise intensity
  • energy restriction
  • metabolism
  • adipose tissue
  • gene expression

Cite this

@article{ad81b1857af045b9aeab9c4acdbf18f8,
title = "The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women",
abstract = "Objective: To establish whether vigorous-intensity exercise offers additional adipose-related health benefits and metabolic improvements compared to energy-matched moderate-intensity exercise.Methods: Thirty-eight sedentary overweight men (n=24) and postmenopausal women (n=14) aged 52 ± 5 years (mean ± SD) were prescribed a 3-week energy deficit (29302 kJ·week-1) achieved by increased isocaloric moderate or vigorous-intensity exercise (+8372 kJ·week-1) and simultaneous restricted energy intake (-20930 kJ·week-1). Participants were randomly assigned to either an energy-matched vigorous (VIG; n=18) or moderate (MOD; n=20) intensity exercise group (five times per week at 70{\%} or 50{\%} maximal oxygen uptake, respectively). At baseline and follow-up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted.Results: Body mass was reduced similarly in both groups (Δ 2.4 ± 1.1 kg and Δ 2.4 ± 1.4 kg, respectively, P<0.05). Insulinaemic responses to a standard glucose load decreased similarly at follow-up relative to baseline in VIG (Δ 8.6 ± 15.4 nmol.120min.l-1) and MOD (Δ 5.4 ± 8.5 nmol.120min.l-1; P<0.05). Expression of SREBP-1c and FAS in adipose tissue was significantly down-regulated whereas expression of PDK4 and HSL was significantly up-regulated in both groups (P<0.05).Conclusions: When energy expenditure and energy deficit are matched, vigorous or moderate-intensity exercise combined with energy restriction provide broadly similar (positive) changes in metabolic control and adipose tissue gene expression.",
keywords = "Exercise intensity, energy restriction, metabolism, adipose tissue, gene expression",
author = "Jean-Philippe Walhin and Dixon, {Natalie C.} and Betts, {James A.} and Dylan Thompson",
year = "2016",
month = "12",
day = "30",
doi = "10.14814/phy2.13026",
language = "English",
volume = "4",
journal = "Physiological Reports",
issn = "2051-817X",
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TY - JOUR

T1 - The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women

AU - Walhin, Jean-Philippe

AU - Dixon, Natalie C.

AU - Betts, James A.

AU - Thompson, Dylan

PY - 2016/12/30

Y1 - 2016/12/30

N2 - Objective: To establish whether vigorous-intensity exercise offers additional adipose-related health benefits and metabolic improvements compared to energy-matched moderate-intensity exercise.Methods: Thirty-eight sedentary overweight men (n=24) and postmenopausal women (n=14) aged 52 ± 5 years (mean ± SD) were prescribed a 3-week energy deficit (29302 kJ·week-1) achieved by increased isocaloric moderate or vigorous-intensity exercise (+8372 kJ·week-1) and simultaneous restricted energy intake (-20930 kJ·week-1). Participants were randomly assigned to either an energy-matched vigorous (VIG; n=18) or moderate (MOD; n=20) intensity exercise group (five times per week at 70% or 50% maximal oxygen uptake, respectively). At baseline and follow-up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted.Results: Body mass was reduced similarly in both groups (Δ 2.4 ± 1.1 kg and Δ 2.4 ± 1.4 kg, respectively, P<0.05). Insulinaemic responses to a standard glucose load decreased similarly at follow-up relative to baseline in VIG (Δ 8.6 ± 15.4 nmol.120min.l-1) and MOD (Δ 5.4 ± 8.5 nmol.120min.l-1; P<0.05). Expression of SREBP-1c and FAS in adipose tissue was significantly down-regulated whereas expression of PDK4 and HSL was significantly up-regulated in both groups (P<0.05).Conclusions: When energy expenditure and energy deficit are matched, vigorous or moderate-intensity exercise combined with energy restriction provide broadly similar (positive) changes in metabolic control and adipose tissue gene expression.

AB - Objective: To establish whether vigorous-intensity exercise offers additional adipose-related health benefits and metabolic improvements compared to energy-matched moderate-intensity exercise.Methods: Thirty-eight sedentary overweight men (n=24) and postmenopausal women (n=14) aged 52 ± 5 years (mean ± SD) were prescribed a 3-week energy deficit (29302 kJ·week-1) achieved by increased isocaloric moderate or vigorous-intensity exercise (+8372 kJ·week-1) and simultaneous restricted energy intake (-20930 kJ·week-1). Participants were randomly assigned to either an energy-matched vigorous (VIG; n=18) or moderate (MOD; n=20) intensity exercise group (five times per week at 70% or 50% maximal oxygen uptake, respectively). At baseline and follow-up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted.Results: Body mass was reduced similarly in both groups (Δ 2.4 ± 1.1 kg and Δ 2.4 ± 1.4 kg, respectively, P<0.05). Insulinaemic responses to a standard glucose load decreased similarly at follow-up relative to baseline in VIG (Δ 8.6 ± 15.4 nmol.120min.l-1) and MOD (Δ 5.4 ± 8.5 nmol.120min.l-1; P<0.05). Expression of SREBP-1c and FAS in adipose tissue was significantly down-regulated whereas expression of PDK4 and HSL was significantly up-regulated in both groups (P<0.05).Conclusions: When energy expenditure and energy deficit are matched, vigorous or moderate-intensity exercise combined with energy restriction provide broadly similar (positive) changes in metabolic control and adipose tissue gene expression.

KW - Exercise intensity

KW - energy restriction

KW - metabolism

KW - adipose tissue

KW - gene expression

UR - http://dx.doi.org/10.14814/phy2.13026

UR - http://dx.doi.org/10.14814/phy2.13026

U2 - 10.14814/phy2.13026

DO - 10.14814/phy2.13026

M3 - Article

VL - 4

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 24

M1 - e13026

ER -