TY - JOUR
T1 - The HPV vaccination strategy: could male vaccination have a significant impact?
AU - Brown, Victoria
AU - White, Katrin
PY - 2010/9
Y1 - 2010/9
N2 - We investigate the potential success of the human papilloma virus (HPV) vaccine, taking into consideration possible waning immunity and the influence of behavioural parameters. We use a compartmental, population-level ordinary differential equation (ODE) model. We find the effective reproductive value for HPV, [image omitted], which measures the threshold for infection outbreak in a population that is not entirely susceptible, together with infection prevalence. We study the effects of different parameters on both of these quantities. Results show that waning immunity plays a large part in allowing infection to persist. The proportion of the population not sexually active when vaccination occurs affects [image omitted], as does the rate at which individuals become sexually active. In several cases, infection persists as a result of an infection reservoir in the male cohort. To explore this further, we introduce male vaccination and find the conditions for which vaccination of males could be considered appropriate.
AB - We investigate the potential success of the human papilloma virus (HPV) vaccine, taking into consideration possible waning immunity and the influence of behavioural parameters. We use a compartmental, population-level ordinary differential equation (ODE) model. We find the effective reproductive value for HPV, [image omitted], which measures the threshold for infection outbreak in a population that is not entirely susceptible, together with infection prevalence. We study the effects of different parameters on both of these quantities. Results show that waning immunity plays a large part in allowing infection to persist. The proportion of the population not sexually active when vaccination occurs affects [image omitted], as does the rate at which individuals become sexually active. In several cases, infection persists as a result of an infection reservoir in the male cohort. To explore this further, we introduce male vaccination and find the conditions for which vaccination of males could be considered appropriate.
KW - reproductive value
KW - mathematical modelling
KW - HPV
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=77955695619&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1080/17486700903486613
U2 - 10.1080/17486700903486613
DO - 10.1080/17486700903486613
M3 - Article
SN - 1748-670X
VL - 11
SP - 223
EP - 237
JO - Computational and Mathematical Methods in Medicine
JF - Computational and Mathematical Methods in Medicine
IS - 3
ER -